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EUS-FNA has excellent diagnostic accuracy for pelvic masses. It represents a safe procedure with excellent yield and thus may be used as a first line modality for the evaluation and diagnosis of pelvic masses within its reach.

Esophageal mucin secretion in patients with reflux esophagitis (RE) is significantly impaired. Rabeprazole augments gastric mucin secretion. We have studied, therefore, the effect of rabeprazole on esophageal mucin secretion in patients with RE. The study was conducted in 15 patients with RE treated with rabeprazole (20 mg QD) for 8 weeks. Esophageal secretions were collected during consecutive infusions of initial NaCl, HCl/Pepsin (HCl/P), and a final NaCl, using a specially designed esophageal catheter, before and after therapy. Mucin was measured using standard methodology. After rabeprazole administration esophageal mucin concentration as well as secretion increased during perfusion with initial saline (P < 0.01), HCl/P (P < 0.02), and concluding saline (P < 0.001). Stimulation of esophageal mucin secretion by rabeprazole may indicate that the mechanisms governing its secretion are similar to those implicated in gastric mucin output. Enhancement of esophageal mucin secretion by rabeprazole may translate into esophagoprotective potential in patients with reflux esophagitis.

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by Rastogi et al. to differentiate between adenoma and hyperplastic polyps (Gastrointest. Endosc. 2008;67:280). These criteria are highly suited to practice in the United states as they are based on non-magnification colonoscopy. Aim: To prospectively validate modified NBI criteria to distinguish between adenomatous and hyperplastic polyps. Methods: We enrolled seven endoscopists without prior experience with NBI to participate in our study. In the white-light phase, endoscopists were asked to predict polyp histology during colonoscopy using standard features observed under white light. After completion of white-light phase, three educational sessions were conducted with each endoscopist to familiarize them with the modified NBI criteria. In the NBI phase, endoscopists were asked to predict polyp histology using the modified NBI criteria. A poster with modified NBI criteria and representative polyp images was available to endoscopists at the time of colonoscopy as reference. Polyp histology served as the criteria standard. All data were prospectively collected. A priori sample size calculation showed that 400 polyps were needed for the study. Results: During the white-light phase, 142 patients underwent colonoscopies and 206 polyps were removed. The average age of study subjects was 59 years and 58% were males. During the NBI phase, 147 patients underwent colonoscopies and 232 polyps were removed. The average age of study subjects was 59 years and 44% were males. The accuracy of white light and NBI in predicting polyp histology for any type of polyp was equivalent for white light and NBI (66% versus 57%; p ϭ0.362) ( Table 1). The accuracy of predicting adenomas for white light and NBI was equivalent (73% versus 65%; pϭ0.426). The accuracy of predicting hyperplastic polyps for white light and NBI was also equivalent (75% versus 64%; pϭ0.27). During the NBI phase, 20 sessile serrated adenomas (SSA) were noted in the study, 15 of which were classified as hyperplastic polyps based on NBI criteria (sensitivityϭ25%) Conclusion: The modified NBI criteria cannot be recommended in clinical practice to select polyps for polypectomy. Further, most SSA were mis-classified as hyperplastic polyps by these criteria. Background: Real time prediction of polyp histology with NBI has the potential Score change from pre-test to post-test. Abstracts www.giejournal.org Volume 75, No. 4S : 2012 GASTROINTESTINAL ENDOSCOPY AB152

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