We present the SEDs of a hard X-ray selected sample containing 136 sources with F 2Y10 keV > 10 À14 erg cm À2 s À1 ; 132 are AGNs. The sources are detected in a 1 deg 2 area of the XMM-Newton Medium Deep Survey where optical data from the VVDS and CFHTLS and infrared data from the SWIRE survey are available. Based on a SED fitting technique we derive photometric redshifts with (1 þ z) ¼ 0:11 and 6% of outliers and identify AGN signatures in 83% of the objects. This fraction is higher than derived when a spectroscopic classification is available. The remaining 17 þ9 À6 % of AGNs show star-forming galaxy SEDs (SF class). The sources with AGN signatures are divided in two classes, AGN1 (33 þ6 À1 %) and AGN2 (50 þ6 À11 %). The AGN1 and AGN2 classes include sources whose SEDs are fitted by type 1 and type 2 AGN templates, respectively. On average, AGN1s show soft X-ray spectra, consistent with being unabsorbed, while AGN2s and SFs show hard X-ray spectra, consistent with being absorbed. The analysis of the average SEDs as a function of X-ray luminosity shows a reddening of the infrared SEDs, consistent with a decreasing contribution from the host galaxy at higher luminosities. The AGNs in the SF classes are likely obscured in the mid-infrared, as suggested by their low L 3Y20 m /L corr 0:5Y10 keV ratios. We confirm the previously found correlation for AGNs between the radio luminosity and the X-ray and the mid-infrared luminosities. The X-rayYradio correlation can be used to identify heavily absorbed AGNs. However, the estimated radio fluxes for the missing AGN population responsible for the bulk of the background at E > 10 keV are too faint to be detected even in the deepest current radio surveys.

Selection of active galactic nuclei (AGN) in the infrared allows the discovery of AGN whose optical emission is extinguished by dust. In this paper, we use the Spitzer Space Telescope First Look Survey (FLS) to assess what fraction of AGN with mid-infrared luminosities comparable to quasars are missed in optical quasar surveys due to dust obscuration. We begin by using the Sloan Digital Sky Survey (SDSS) database to identify 54 quasars within the 4 deg 2 extragalactic FLS. These quasars occupy a distinct region in mid-infrared color space by virtue of their strong, red, continua. This has allowed us to define a mid-infrared color criterion for selecting AGN candidates. About 2000 FLS objects have colors consistent with them being AGN, but most are much fainter in the mid-infrared than the SDSS quasars, which typically have 8µm flux densities, S 8.0 , ∼ 1mJy. We have investigated the properties of the 43 objects with S 8.0 ≥ 1mJy satisfying our AGN color selection. This sample should contain both unobscured quasars, and AGN which are absent from the SDSS survey due to extinction in the optical. After removing 16 known quasars, three probable normal quasars, and eight spurious or confused objects from the initial sample of 43, we are left with 16 objects which are likely to be obscured quasars or luminous Seyfert-2 galaxies. This suggests the numbers of obscured and unobscured AGN are similar in samples selected in the mid-infrared at S 8.0 ∼ 1mJy.

Using the large multiwavelength data set in the Chandra/SWIRE Survey (0.6 deg 2 in the Lockman Hole), we show evidence for the existence of highly obscured (Compton-thick) AGNs, estimate a lower limit to their surface density, and characterize their multiwavelength properties. Two independent selection methods based on the X-ray and infrared spectral properties are presented. The two selected samples contain (1) five X-ray sources with hard X-ray spectra and column densities k10 24 cm À2 and (2) 120 infrared sources with red and AGN-dominated infrared SEDs. We estimate a surface density of at least 25 Compton-thick AGNs deg À2 detected in the infrared in the Chandra/ SWIRE field, of which $40% show distinct AGN signatures in their optical/near-infrared SEDs, the remaining being dominated by the host galaxy emission. Only $33% of all Compton-thick AGNs are detected in the X-rays at our depth [F(0:3 8 keV) > 10 À15 ergs cm À2 s À1 ]. We report the discovery of two sources in our sample of Comptonthick AGNs, SWIRE J104409.95+585224.8 (z ¼ 2:54) and SWIRE J104406.30+583954.1 (z ¼ 2:43), which are the most luminous Compton-thick AGNs at high z currently known. The properties of these two sources are discussed in detail with an analysis of their spectra, SEDs, luminosities, and black hole masses.

The SIRTF Wide-area InfraRed Extragalactic survey (SWIRE), the largest SIRTF Legacy program, is a wide-area, imaging survey to trace the evolution of dusty, starforming galaxies, evolved stellar populations, and AGN as a function of environment, from redshifts z∼3 to the current epoch. SWIRE will survey 7 high-latitude fields, totaling 60-65 sq. deg. in all 7 SIRTF bands: IRAC 3.6, 4.5, 5.6, 8µm and MIPS 24, 70, 160µm. Extensive modeling suggests that the Legacy Extragalactic Catalog may contain in excess of 2 million IR-selected galaxies, dominated by (1) ∼150,000 luminous infrared galaxies (LIRGs: L F IR > 10 11 L ⊙) detected by MIPS (and significantly more detected by IRAC), ∼7,000 of these with z>2; (2) 1 million IRAC-detected early-type galaxies (∼ 2×10 5 with z > 1 and ∼10,000 with z > 2); and (3) ∼ 20,000 classical AGN detected with MIPS, plus significantly more dust-obscured QSO/AGN among the LIRGs. SWIRE will provide an unprecedented view of the evolution of galaxies, structure, and AGN. The key scientific goals of SWIRE are: (1) to determine the evolution of actively star-forming and passively evolving galaxies in order to understand the history of galaxy formation in the context of cosmic structure formation; (2) to determine the evolution of the spatial distribution and clustering of evolved galaxies, starbursts and AGN in the key redshift range, 0.5

In the original paper, both axes of Figure 1a show units that are a factor of 1000 times too large. The corrected version is shown here. Fig. 1.-(a) 20 cm radio and 70 m IR luminosity correlation (see text) for the FLS long-wavelength sample and the distribution of monochromatic q 70 -values with redshift (b) uncorrected and (c) k-corrected using the DH01 SED-fitting method described in the text for the IR flux densities and assuming a (1 þ z) 0:7 k-corrected (boosting) of the 1.4 GHz values.

Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is dramatically different, as humans have a higher percent of glycine conjugated bile acids and increased chenodeoxycholate content, which increases the hydrophobicity index of bile acids. This increase may lead to direct toxicity that kills hepatocytes, and promotes inflammation. To address this issue, this study assessed how pathophysiological concentrations of bile acids measured in cholestatic patients affected primary human hepatocytes. Individual bile acid levels were determined in serum and bile by UPLC/QTOFMS in patients with extrahepatic cholestasis with, or without, concurrent increases in serum transaminases. Bile acid levels increased in serum of patients with liver injury, while biliary levels decreased, implicating infarction of the biliary tracts. To assess bile acid-induced toxicity in man, primary human hepatocytes were treated with relevant concentrations, derived from patient data, of the model bile acid glycochenodeoxycholic acid (GCDC). Treatment with GCDC resulted in necrosis with no increase in apoptotic parameters. This was recapitulated by treatment with biliary bile acid concentrations, but not serum concentrations. Marked elevations in serum full-length cytokeratin-18, high mobility group box1 protein (HMGB1), and acetylated HMGB1 confirmed inflammatory necrosis in injured patients; only modest elevations in caspase-cleaved cytokeratin-18 were observed. These data suggest human hepatocytes are more resistant to human-relevant bile acids than rodent hepatocytes, and die through necrosis when exposed to bile acids. These mechanisms of cholestasis in humans are fundamentally different to mechanisms observed in rodent models.

LBC are at risk to develop emotional/behavior problems, particularly if they are left behind early in life, for longer periods, in the care of young caregivers or nonrelatives with poor education and low socioeconomic status, and with less teacher support. Strategies to prevent the development of psychopathology and its amelioration, and governmental policies to decrease the rates of LBC are warranted.

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