Many physiologic differences between children and adults may result in age-related changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and emptying time, intestinal transit time, immaturity of secretion and activity of bile and pancreatic fluid among other factors determine the oral bioavailability of pediatric and adult populations. Anatomical, physiological and biochemical characteristics in children also affect the bioavailability of other routes of administration.Key factors explaining differences in drug distribution between the pediatric population and adults are membrane permeability, plasma protein binding and total body water. As far as drug metabolism is concerned, important differences have been found in the pediatric population compared with adults both for phase I and phase II metabolic enzymes. Immaturity of glomerular filtration, renal tubular secretion and tubular reabsorption at birth and their maturation determine the different excretion of drugs in the pediatric population compared to adults.

Abstract:In this paper we provide evidence of the temporal fluctuations of the phase modulation property of a liquid crystal on silicon (LCoS) display, and we analyze its effect when the device is used for displaying a diffractive optical element. We use a commercial twisted nematic LCoS display configured to produce a phase-only modulation, and we provide time resolved measurements of the diffraction efficiency that show rapid fluctuations of the phase modulation, in the millisecond order. We analyze how these fluctuations have to be considered in two typical methods for the characterization of the phase modulation: two beam interference and diffraction from a binary grating. We finally provide experimental results on the use of this device for displaying a computer generated hologram. A reduction of the modulation diffraction efficiency results from the phase modulation fluctuation. Opt. Eng. 29, 240-246 (1990

Photopolymers that absorb in the visible spectrum are useful for different applications such as in the development of holographic memories, holographic optical elements or as holographic recording media. Photopolymers have an undesirable feature, the toxicity of their components and their low environmental compatibility, particularly if we analyse the life cycle of the devices made with these materials and their interaction with the environment. In this work we developed a new photopolymer with photochemical and holographic features similar to those of the standard material but with an improved design from the environmental point of view.

No abstract

Abstract:In this paper we experimentally analyze the performance of a twisted nematic liquid crystal on silicon (LCoS) display as a function of the angle of incidence of the incoming beam. These are reflective displays that can be configured to produce amplitude or phase modulation by properly aligning external polarization elements. But we demonstrate that the incident angle plays an important role in the selection of the polarization configuration. We performed a Mueller matrix polarimetric analysis of the display that demonstrates that the recently reported depolarization effect observed in this type of displays is also dependant on the incident angle.