Dipalmitoylphosphatidylcholine (DPPC) and 1,2-palmitoyl-phosphatidic acid (DPPA) liposomes, prepared by conventional rotary evaporation method, have similar structural organization, though they have significant differences. The similarity is that both types of lipids create standard bilayer liposomes with strong hydrophobic forces between lipids tails and with homogeneous bonds of hydrogen and electrostatic nature between hydrophilic lipids heads. By the calorimetric method, it has been shown that hydrophobic bonds break but liposomes' destruction does not occur by heating till 150 °C. As for bonds between lipid heads in liposomes, their cooperative destruction takes place at 41 °C for DPPC and 66 °C for DPPA liposomes. In the case of thermal distraction of DPPC liposomes, two so-called pre transitions peaks were observed before the main transition peak, which indicates that DPPC liposomes' structure is multilamellar. DPPA liposomes have one cooperative heat absorption peak, which points to a unilamellar structure of such liposomes. Substances of hydrophobic/hydrophilic nature, incorporated into the liposomes, are placed in hydrophobic or hydrophilic parts of liposomes, which lead to a change in calorimetric peak shapes and thermodynamic parameters. It has been shown that gold nanoparticles, incorporated into the DPPC liposomes, are able to enter Caco-2 cells. In contrast, these nanoparticles do not enter red blood cells.
Background: Recovery of dental arch defects, related to insertion of a foreign bodies into the oral cavity, and the impact of mechanical pressure, allergic-toxic effects, and the related inflammatory and degenerative processes is one of the most urgent problems in dentistry.The purpose of the study was to evaluate the efficacy of Georgian bean extract tincture as mouthwash for patients using a lever system to correct deformities of the jaw and teeth.Methods: Twenty-eight patients (aged 12-25 years) with deformities of the jaw and teeth were studied. Patients were examined 6-8 months after the bracket system was installed, and before and after the use of tincture mouthwash for 10 days. Patients were randomly divided into 2 groups: the control group for the mouthwash used standard tincture ("Octenidol" Schulke and Mayr -Germany); the patients of the experimental group used tincture made from the Georgian legume crop extracts (GLCE). Before and after the use of both types of tincture, the data were taken for calculation of Schiller Pisarev's test (SPT), Papillary-Marginal Alveolar (PMA) index, and the oral hygiene index (OHI). Saliva was collected in a glass tube without stimulation, on an empty stomach. The content of cytokines IL-1β, IL-10 in saliva was determined by the ELISA kit.Results: The study demonstrated significant positive clinical efficacy of the mouthwash tincture prepared from the GLCE which increases the resistance of dental tissue. This was revealed by significantly lower values of OHI, PMA index, SPT and increased content of IL-10 in saliva.This data indicates that tincture prepared from the Georgian legume crop extracts, which is designed to increase the stability of oral tissue, does promote an increase in resistance to the aggressive mechanical pressing.Conclusion: Tincture from the GLCE is characterized by a much stronger anti-inflammatory effect than standard tincture "Octenidol" (Schulke and Mayr -Germany) used against inflammation of the oral cavity soft tissue. This allows us to recommend the tincture from the GLCE for the treatment and prevention of inflammatory processes in the oral cavity soft tissue.Keywords: Georgian legumes crop extracts (GLCE), oral cavity soft tissue inflammation, Hygiene Index, PMA index, Schiller Pisarev's test.
Diagnostic markers are important indicators for the assessment of the possible consequences of radiation exposure, which could lead to acute and chronic radiation toxicity. The goal of the study is to determine high-sensitive markers of blood redox status in relation to the dose of radiation. The mice were exposed to γ-irradiation (Cs137) at a total dose of 3, 5, and 7Gy. After 1, 2, 7, and 14 days of the irradiation, the blood samples were drawn under ether anesthesia from the inferior vena cava and the activity of antioxidant system (enzymatic -superoxide dismutase (SOD), catalase) and non-enzymatic total antioxidant activity (TAA) of blood serum was determined. The results of our investigation support the fact that the non-enzymatic antioxidant TAA plays an important role in the prevention of radiation damage during ionizing radiation exposure, which makes it possible to consider TAA as a promising candidate as the biomarker of radiation dose.
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