Background: The role of serum zinc, and magnesium concentration activities in association with the Blood sugar level, and their link as biochemical marker risk for lens damage, inflammation, for the Retinal disease patients with diabetes beside lens replacement surgery, and in control individuals for both genders. Our purpose for the current study is to investigate serum concentration levels of blood sugar, zinc, and magnesium, as trace elements for patients with retinal diseases with diabetes in correlation with healthy subjects, and their effect on eye function, lens damage, inflammation, and bacterial or viral infections, or even undergo artificial intraocular lens surgery. Also to find a diagnostic prediction for blood sugar, magnesemia and zinc levels may induce causing diabetes retinopathy, cataract, or even glaucoma. Materials and methods: Total of forty six diabetic retinopathy patients their mean is (53.36±16.3), and thirty four healthy controls with mean of (49.91±21.72) have been studied. The age has non-significantly (P>0.05) differ in diabetic retinopathy patients (53.36±16.31 year) from normal subjects (49.91±21.72 year). Retinal disease patients are diagnosed on the basis of pathological condition into diabetic retinopathy patients. Results: Assessment, of serum zinc, and magnesium, and blood glucose levels were done for all groups. The concentricity of serum zinc levels are depressed, and non-significantly differ for diabetic retinopathy patients, higher in (33±19.48 ng/L with P= 0.122), from that of normal subjects. Whilst the level of magnesium was exhibited to be decreased for diabetic retinopathy patients, they showed (1.74±0.34 ng/L with P = 0.390) from that of normal subjects. Moreover, blood sugar levels are increased in diabetes than control (10.27±4.62 μmol/L versus 5.23±0.40 μmol/L with P = 0.0001). All parameters has are correlated non-significantly association with each other for diabetic retinopathy patients.
There are scarce evidences about the effects of herbs on nitrogen species that induced nitrosative stress. We here investigated the effect of simple water distilled extract of dry leaves salvia officinalis (sage) and Ruta graveolens (Rue) on the nitric oxide (NO) -peroxynitrite (ONOO -) cycle biochemistry in vitro experiments. Aqueous extract of sage or rue (1%) were prepared by simple distillation and scanned by UV-visible spectrophotometer. Their effects were studied on the synthesized ONOOas well as their ability to generate ONOO. It is ability to donate NO or to scavange released NO by sodium nitroprusside (10 mM) also investigated. UV-visible scan of sage extract revealed the presence of peaks at λ195 and 348.5 while that of rue extract at λ 200, λ242, λ291.5. Both extracts not generate ONOOradical in form of nitrophenols. Rue extract increased the yield of prepared ONOOby more than five times. Rue extract donated NO and improved the release NO from sodium nitroprusside while sage extract only improved the release of NO released by sodium nitroprusside. We conclude that simple distilled -aqueous extract of rue and sage extracts improved nitric oxide bioavailability that may be helpful in coronary artery disease with nitrate tolerance.
BACKGROUND Preeclampsia (PE) is a multisystemic metabolic disease with an undetermined etiology. PE is a worldwide cause of maternal and perinatal morbidity, subdivided into early (EoPE) and late-onset (LoPE) according to 34 wk of gestation as a divider. Many researchers investigated biomarkers for predicting PE to halt its consequences on the feto-maternal outcome. Elabela (Ela) is a newly discovered peptide hormone that was implicated in PE pathogenesis. Earlier rodent studies discussed Ela’s role in controlling blood pressure. Moreover, Ela deficiency was associated with PE development. AIM To test whether plasma Ela could serve as a reliable marker for predicting PE based on the time of onset (EoPE vs LoPE) compared to age and body mass matched healthy controls since no definitive treatment exists for PE but to terminate a pregnancy. METHODS This case-control study recruited ( n = 90) pregnant who fulfilled inclusion criteria; they were allocated into three groups: EoPE (30/90) (< 34 wk of gestation); LoPE (30/90) (≥ 34 wk of gestation); and healthy pregnant (30/90). Demographic criteria; biochemical, hematological, and maternal plasma Ela levels were recorded for comparison. RESULTS Serum Ela was significantly reduced in EoPE compared to LoPE and healthy controls ( P = 0.0023). The correlation confirmed a strong inverse relationship with mean atrial blood pressure ( r = -0.7, P < 0.001), while gestational age and platelets count showed a moderate correlation with ( r = 0.4 with P < 0.0001). No correlation was confirmed between the body mass index (BMI) and urine albumin. The predictive ability of 25 centile serum Ela had an Odds ratio of 5.21, 95% confidence interval (1.28, 21.24), P = 0.02 for predicting EoPE. The receiver operator characteristic curve defined the Ela cutoff value at > 9.156 with 96.7% and 93.3% sensitivity and specificity, P < 0.0001 in predicting EoPE. CONCLUSION A strong correlation of serum Ela with PE parameters with excellent sensitivity and specificity in distinguishing EoPE independent of the BMI, age, and blood pressure which makes Ela a recommendable marker in screening. Further research is warranted to explore prognostic and therapeutic applications for Ela in PE.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.