Purpose: Analyze the influence of low-intensity laser therapy in the sciatic nerve regeneration of rats submitted to controlled crush through histological analysis. Methods: Were used 20 Wistar rats, to analyze the influence of low-intensity laser therapy in the sciatic nerve regeneration, where the injury of the type axonotmesis was induced by a haemostatic clamp Crile (2nd level of the rack). The animals were randomly distributed in 2 groups. Control group (CG n = 10) and Laser group (LG n = 10). These were subdivided in 2 subgroups each, according to the euthanasia period: (CG14 -n = 5 and CG21 -n = 5) and (LG14 -n = 5 and LG21 -n = 5). At the end of treatment, the samples were removed and prepared for histological analysis, where were analyzed and quantified the following findings: Schwann cells, myelinic axons with large diameter and neurons. Results: In the groups submitted to low-intensity laser therapy, were observed an increase in the number of all analyzed aspects with significance level. Conclusion: The irradiation with low intensity laser (904nm) influenced positively the regeneration of the sciatic nerve in Wistar rats after being injured by crush (axonotmesis), becoming the nerve recovery more rapid and efficient.

Introdução: As doenças cardiovasculares são a principal causa de óbito no mundo. As taxas de morte continuam elevadas e podem ser decorrentes da alta prevalência e, ao mesmo tempo, do ainda pobre controle dos fatores de risco cardiovascular. Métodos: Trata-se de estudo analítico e observacional realizado em ambulatório de Cardiologia no período de agosto de 2015 a agosto de 2016, por meio de aplicação de questionário próprio. Os dados passaram por análise estatística descritiva e foram respeitadas as recomendações éticas. Objetivos: Estimar a prevalência e a distribuição da combinação de fatores de risco cardiovascular em portadores de doença arterial coronariana, bem como avaliar o conhecimento de antecedentes pessoais de risco. Resultados: Houve predomínio do sexo feminino (70%), com média de idade de 63,87 anos. A maioria declarou-se parda (75,56%), solteira (41,11%), com baixa escolaridade (57,79%) e renda (61,11%) e sem atividade ocupacional (56,67%). A maioria dos indivíduos teve como diagnóstico médico a angina instável (74,44%). Observou‑se elevada prevalência de fatores de risco cardiovascular, principalmente hipertensão arterial sistêmica (83,33%), dislipidemia (62,22%), sedentarismo (74,44%) e excesso de peso (64,44%). A obesidade central foi identificada em 88,89% das mulheres e em 51,85% dos homens. Segundo o índice de massa corpórea, a obesidade foi encontrada em 37,78% da amostra. Acerca do conhecimento, 74,44% dos sujeitos afirmaram saber as condições que predispõem doença arterial coronariana. O fumo (36,67%) e a hipertensão arterial sistêmica (34,44%) foram os fatores de risco cardiovascular mais citados. Conclusão: Observou-se conhecimento insatisfatório acerca dos fatores de risco cardiovascular, bem como um descontrole e alta prevalência de fatores de risco. A caracterização dos fatores de risco cardiovascular é essencial para a realização de intervenções mais custo-efetivas.

PURPOSE:To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/ polyglecaprone mesh in rats. METHODS:A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS:All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION:Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.

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PURPOSE:To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed.The Kaplan-Meier curves of surviving time were realized. RESULTS:All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05) CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.