Acid. -The title compounds are prepared in two consecutive biocatalytic steps. The first step involves the lipase catalyzed esterification of oxoglutaric acid (I). The second step involves the reduction of the resulting esters by use of fresh or freeze-dried yeast-like cells of Mucor rouxii. By use of freeze-dried cells, either hydroxyesters or lactones are formed, depending on the length of the alkyl chain in the ester. -(RUSTOY, E. M.; PEREYRA, E. N.; MORENO, S.; BALDESSARI*, A.; Tetrahedron: Asymmetry 15
The absolute stereochemistry of novel chiral N-(2-hydroxylalkyl)acrylamides prepared by a lipase-catalyzed resolution was successfully determined by 1H NMR of their MTPA esters. The method was validated for this particular case by computational experiments.
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