Biocatalytic synthesis of chiral<i>N</i>-(2-hydroxyalkyl)-acrylamides

Monsalve, Leandro N.; Rustoy, Eduardo Miguel; Baldessari, Alicia

doi:10.3109/10242422.2011.578212

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Chemical shifts are reported in units (ppm) relative to tetramethylsilane (TMS) set at 0 ppm, and coupling constants are given in hertz. The synthesis of N-(2-hydroxyalkyl)acrylamides 2a-d and their corresponding MTPA derivatives 3a-d and 4a-d were performed as described previously [11].…”

Section: Methodsmentioning

confidence: 99%

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A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides

Rustoy

Baldessari

Monsalve

2014

Advances in Chemistry

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Section: Methodsmentioning

confidence: 99%

“…We have previously performed a lipase-catalyzed synthesis of nonchiral and chiral N-(2-hydroxyalkyl)acrylamides (Scheme 1) [10,11].…”

Section: Introductionmentioning

confidence: 99%

A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides

Rustoy

Baldessari

Monsalve

2014

Advances in Chemistry

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Biokatalysatoren für die organische Synthese – die neue Generation

et al. 2014

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Die Verwendung von Enzymen als Katalysatoren zur Synthese neuartiger Verbindungen ist in den letzten Jahren zunehmend in den Fokus gerückt. Entsprechend hohe Erwartungen werden an die Entdeckung und Identifizierung neuer Biokatalysatoren für die organische Synthese gestellt. Dies spiegelt sich auch in der Komplexität der adressierten Reaktionen wider. Der Anwendungsbereich von Biokatalysatoren umfasst die Synthese wichtiger Zwischenprodukte für die pharmazeutische und chemische Industrie sowie die Entwicklung neuer enzymatischer Techniken und Prozesse. Enzyme sind ein wichtiger Teil des Spektrums an Katalysatoren, die der Synthesechemie zur Verfügung stehen. Die Vorteile und Anwendungsmöglichkeiten der neuesten und höchst vielversprechenden Generation von Biokatalysatoren – Reduktasen, Transaminasen, Ammoniak‐Lyasen, Epoxidhydrolasen und Dehalogenasen – werden hier vorgestellt und anhand der Synthese von Schlüsselmolekülen beispielhaft diskutiert.

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New Generation of Biocatalysts for Organic Synthesis

et al. 2014

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The use of enzymes as catalysts for the preparation of novel compounds has received steadily increasing attention over the past few years. High demands are placed on the identification of new biocatalysts for organic synthesis. The catalysis of more ambitious reactions reflects the high expectations of this field of research. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies and processes have been established. Enzymes are an important part of the spectrum of catalysts available for synthetic chemistry. The advantages and applications of the most recent and attractive biocatalysts--reductases, transaminases, ammonia lyases, epoxide hydrolases, and dehalogenases--will be discussed herein and exemplified by the syntheses of interesting compounds.

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Biocatalytic synthesis of chiralN-(2-hydroxyalkyl)-acrylamides

Cited by 7 publications

References 27 publications

A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides

A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides

Biokatalysatoren für die organische Synthese – die neue Generation

New Generation of Biocatalysts for Organic Synthesis

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