Background: In dogs, bullous pemphigoid (BP) is a subepithelial autoimmune disease, a rare dermatopathy in the clinical routine. BP is characterized by formation of vesicles and subepidermal blisters that result from dissolution of the dermal-epithelial junction. Clinical signs of BP usually include severe dermatological alterations with a variable prognosis. The aim of this work is to report a case of BP in a dog to contribute information for diagnosis, and to present clinical and pathological aspects that emerge during development of BP.Case: An adult male mongrel dog exhibited hyperemic, exudative, crusty lesions on the lip commissure and periocular areas. Results from laboratory tests were normal. Results from parasitological and mycological tests on skin scrapings were negative. Imprint cytology of the crusts revealed presence of gram-positive cocci bacteria. In the histopathological analysis of punch biopsy material, the epidermis was detached from the dermis, leading to formation of vesicles. There were inflammatory infiltrates containing neutrophils, eosinophils, and high amounts of fibrin, and areas of multifocal orthokeratotic hyperkeratosis. Multifocal infiltrates containing lymphocytes, histiocytes, and plasma cells were observed on the superficial portions of the dermis, which indicated a diagnosis of BP. After the definitive clinical diagnosis, the animal was treated with enrofloxacin (Baytril Flavour®; 5 mg/kg once a day for 10 days), and prednisolone (Prediderm®; 2 mg/kg once a day until further instructions). On the follow-up visit, 15 days later, the clinical picture had improved, and the lesions had decreased. Continuity of the treatment was prescribed, along with a gradual decrease in the corticoid dose. The dose of prednisolone was initially reduced to 1 mg/kg once a day, and later to 0.5 mg/kg until improvement of the clinical status of the patient. Remission of the lesions was observed 13 weeks later.Discussion: The diagnosis of BP was established after identification of the clinical cutaneous lesions and observation of microscopic findings on punch biopsy material obtained from the ocular and lip regions. BP does not exhibit breed or sex predisposition, and affects adult dogs. The clinical signs of BP are characteristic of autoimmune diseases that affect the dermoepidermal junction, and consist of erythematous, ulcerated, crusty, and painful lesions on the nose, dorsal area of the muzzle, and periorbital region. However, these lesions must be differentiated, by histological analysis, from several other conditions with a similar clinical presentation. Diseases that must be considered in the differential diagnosis comprise other variants of the pemphigus complex, lupus erythematosus, drug eruption, erythema multiforme, toxic epidermal necrolysis, epitheliotropic lymphoma, inherited bullous epidermolysis, mucous membrane pemphigoid, and lymphoreticular neoplasia. The clinicopathological findings indicated that the lesions were compatible with BP. The occurrence of necrotic and erythematous lesions is due to production of antibodies accompanied by a strong response of neutrophils, which results in loss of cell adhesion and epidermal necrosis. The presence of detachment of the epidermis from the dermis, inflammation in the superficial portion of the dermis, and infiltrates containing lymphocytes, histiocytes and plasma cells observed at the histopathological examination indicated the occurrence of BP. The skin histopathological examination warranted establishment of a diagnosis and therapeutic success. The lack of recurrence of clinical manifestations 43 weeks after the end of the glucocorticoid treatment demonstrated that the therapeutic approach and the cooperation of the owner are essential for success of the treatment.
O presente trabalho apresenta relato de craniectomia descompressiva em raposa (Cerdocyon thous), macho, jovem, após diagnóstico de trauma cranioencefálico. O paciente foi graduado pela escala de Glasgow modificada como grave (grau 7), e por não ter apresentado melhora durante as primeiras quatro horas de tratamento, optou-se então pelo procedimento cirúrgico de craniectomia descompressiva com o intuito de diminuir a pressão intracraniana para prevenção e controle de danos do sistema nervoso. O paciente apresentou melhoras progressivas, após 60 dias obteve alta. A sequela observada nesse caso foi de déficit visual do olho direito, retornando com a movimentação e resposta ao ambiente. Após alta médica o paciente foi encaminhado a zoológico, mostrou interação com outros indivíduos da mesma espécie e reproduziu com uma fêmea do mesmo recinto. What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy What do you want to do ? New mailCopy
RESUMO.O presente relato tem como objetivo descrever um caso de obstrução uretral em um felino macho, sem raça definida de três meses de idade. Suspeitou-se de um quadro obstrutivo durante a anamnese e exame físico, ao qual o paciente se encontrava apático, estado de desidratação leve e vesícula urinária distendida. Após realização de exames complementares, realizaram-se três tentativas de sondagem uretral com cateter intravenoso flexível, ambas demonstrando insucesso. O paciente então, foi encaminhado para cirurgia, procedendo-se amputação total peniana, orquiectomia e uretrostomia perineal; porém devido intercorrências anestésicas o paciente veio a óbito em virtude de duas paradas respiratórias e duas cardiorrespiratórias.Palavras chave: Gato, obstrução, tampão uretral. Perineal urethrostomy in obstructed feline from three months old: Case reportABSTRACT. The present report aims to describe a case of urethra lobstruction in a feline, male, without race defined three months of age. The suspected of a obstructive frame was during anamnesis and physical examination, to which the patient was lethargic, mildde hydration state and distended urinary bladder. After additional tests, were performed three triesurethral probing with intravenous catheter flexible, both failure demonstrating. The patient was referred for surgery, which amputation of the penis, orchiectomy and perineal urethrostomy. However, because of anesthetic complications the patient came to death in virtue of two stops respiratory and two cardio respiratory.
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