No abstract

Ectopic breast tissue has the ability to undergo all the pathological changes of the normal breast, including breast cancer. Gastrointestinal metastasis of breast cancer is rarely observed and it is very difficult to differentiate gastric metastases from primary gastric cancer. We present a case of 52-year-old female, who suffered from abdominal pain. Physical examination showed a palpable mass in the left anterior axilla and computerized tomography revealed gastric wall thickening with linitis plastica. When gastroscopic biopsy showed no signs of malignancy, excisional biopsy was performed in the left axilla. Histological examination revealed invasive lobular carcinoma of the breast, consistent with ectopic breast cancer. Further gastroscopic submucosal biopsies and immunohistochemical studies revealed gastric metastases of invasive lobular carcinoma. Axillary ectopic breast tissue carcinomas can mimic axillary lymphadenopathies. Additionally, gastric metastasis of breast cancer is an uncommon but possible condition. To the best of our knowledge, this is the first report of ectopic breast cancer with gastric metastasis.

Consistent with previous findings in the literature, the NS-coated polypropylene graft was seen to have a significantly better bactericidal effect than the normal polypropylene graft. Development of NS-coated grafts seems to be a reliable and applicable method to reduce the incidence of postoperative graft infection.

Amaç: Prematüre retinopatisi (PR) açısından taranan bebeklerde tedavi gerektiren PR görülme oranını saptamak, bu oranın doğum haftası ve doğum ağırlığıyla ilişkisini incelemek, ülkemiz için uygun tarama kriterlerini tartışmak. Gereç ve Yöntem: Prematüre retinopatisi taraması kapsamında muayenesi yapılan, doğum kilosu ≤2000 gram (g) ve/veya doğum yaşı ≤34 hafta olan prematüre bebeklerin dosya kayıtları incelendi. Olgular doğum ağırlığına göre ≤1000 g, 1001-1500 g, >1500 g, gestasyonel yaşa göre ise ≤27 hafta, 28-31 hafta, ≥32 hafta olmak üzere gruplara ayrıldı. Bu gruplarda tedavi gereken PR gelişim oranları incelendi. Tedavi edilmesi gereken hastaların doğum ağırlıkları ve doğum yaşları analiz edildi. Bulgular: Muayene edilen 1250 prematüre bebeğin 100'ünde (%8) tedavi gerektirecek düzeyde PR saptandı. Tedavi kararı verilen bebeklerin gestasyonel yaşı ortalama 28,3±2,3 (24-34) hafta; doğum ağırlığı ise ortalama 1152,2±396 (520-2120) gramdı ve tedavi gerekmeyen hastalara göre anlamlı olarak düşük bulundu (p<0,001). Doğum ağırlığına göre gruplara bakıldığında ≤1000 g doğan 202 bebeğin 45'inde (%22,3), 1001-1500 g arasında doğan 488 bebeğin 39'unda (%8), >1500 g doğan 560 bebeğin 16'sında (%2,9) tedavi endikasyonu mevcuttu. Doğum haftasına göre değerlendirildiğinde ise ≤27 hafta doğan 170 hastanın 33'ünde (%19,4), 28-31 hafta arasında doğan 572 hastanın 59'unda (%10,3), ≥32 hafta doğan 508 bebeğin 8'inde (%1,6) tedavi gereken ileri evre PR saptandı. Sonuç: Prematür retinopatisine bağlı görme kaybının önüne geçebilmenin en iyi yolu, tedavi gerekebilecek bebekleri tümüyle içerecek şekilde düzenli bir tarama programı oluşturmaktır. Bu bağlamda ülkemiz için tarama sınırlarının gelişmiş ülkelerde uygulanandan geniş tutulmasını, ≤34 hafta ve/ veya ≤2000 g doğan bebeklerin PR açısından taranmasını önermekteyiz. (Turk J Ophthalmol 2014; 44: 42-6) Anahtar Kelimeler: Prematüre retinopatisi, tarama kriterleri, doğum ağırlığı, gestasyonel yaş Objectives: To determine the rate of infants with retinopathy of prematurity (ROP) requiring treatment, to investigate the relation of this rate with birth age and birth weight, and to discuss the screening criteria eligible for our country. Materials and Methods: Medical records of premature infants examined for ROP with birth weight ≤2000 gram (g) and/or gestational age ≤34 weeks were evaluated. Patients were grouped according to their birth weights as ≤1000 g, 1001-1500 g, >1500 g, and according to gestational age as ≤27 weeks, 28-31 weeks, ≥32 weeks. The rate of patients with treatment-requiring ROP was evaluated in these groups. The birth weights and gestational ages of these patients were analyzed. Results: Treatment requiring ROP stages were detected in 100 (8%) of 1250 infants. The mean gestational age and birth weight of these patients was 28.3±2.3 (24-34) weeks and 1152.2±396 (520-2120) g respectively, and both were found lower than those of nontreated infants (p<0.001). Regarding the birth weight, 45 (22.3%) of 202 infants ≤1000 g, 39 (%8) of 488 infants between 1001-1500 g, 16...

Background In-transit metastasis is considered a locoregional disease in cutaneous melanoma (CM) patients. Isolated limb perfusion (ILP) is among the treatment options in selected cases. The aim of this study was to determine the success of pre- and post-perfusion mSIS values in predicting the potential complications and the prognosis of the disease by investigating the early and long-term results of mSIS values calculated before and after ILP in CM cases with in-transit metastases. Materials and methods Patients who underwent ILP within the period from 2014 to 2020 in our department were retrospectively scanned. A total of 20 patients were found to undergo ILP. The scores obtained from modified inflammation score (mSIS) were formulated according to albumin (Alb) and lymphocyte to monocyte ratio (LMR) scores. Results The mean follow-up time was 20.47 months. Complications requiring surgical intervention developed in three patients. According to the Wieberdink local toxicity classification, the majority (70%) of the patients were found to be grade II. Based on pre-perfusion mSIS values, 8 patients were classified as mSIS 0 while six patients were classified as mSIS 1 and 2. Based on post-perfusion mSIS values, 14 patients and one patient were classified as mSIS 2 (70%) and mSIS 0, respectively. Accordingly, univariate analysis showed that mSIS 1 and mSIS 2 were negative prognostic factors for mean survival in the pre-perfusion period (HR 0.162, 95% CI 0.036–0.729; p = 0.018 and HR: 0.223, 95% CI 0.049–1.019; p = 0.053) whereas albumin (Alb) and lymphocyte to monocyte ratio (LMR) were not independent prognostic factors for mean survival. Conclusion The mSIS values calculated in the pre-perfusion period can give an opinion about the OS of the patients whereas post-perfusion mSIS values may predict potential surgical complications and local toxicities.