Results of Screening for Retinopathy of Prematurity: How the Ideal Screening Program Should Be?

Esen, Ebru; Erdem, Elif; Yar, Kemal; Demircan, Nihal; Soylu, Merih

doi:10.4274/tjo.72621

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…In developing countries, infants with higher BW and GA are at risk for ROP development. 20 , 21 Therefore, the current study consisted of infants with a GA ≤34 weeks. In a recent ROP study, fundus examinations of infants with GA ≤34 weeks or BW <1,700 g was recommended for Turkey.…”

Section: Discussionmentioning

confidence: 99%

Impact of Platelet Count in Retinopathy of Prematurity

Şahinoğlu-Keşkek

Gülcan

Yılmaz

et al. 2020

tjo

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Section: Discussionmentioning

confidence: 99%

Impact of Platelet Count in Retinopathy of Prematurity

Şahinoğlu-Keşkek

Gülcan

Yılmaz

et al. 2020

tjo

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“…As a result, VEGF, which is secreted excessively and uncontrollably from the immature avascular retinal tissue that remains ischemic, thus causing pathological vascularization, has an important place in the pathogenesis of ROP ( 12 ). Based on all these, increasing VEGF levels in the vitreous trigger the development of ROP ( 13 ). After understanding the importance of increased vitreous VEGF concentration in the pathophysiology of ROP, intravitreal anti VEGF treatments have become almost the main treatment in ROP cases requiring treatment, and laser photocoagulation treatment of the avascular retina is mostly used as a complementary treatment to anti VEGF treatment ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Can Serum Biomarker Values from Second-Trimester Aneuploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants?

Sabanci

2024

Beyoglu Eye J

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Objectives: This study aimed to evaluate serum biomarker values measured during second-trimester aneuploidy screening in terms of their predictive ability for the development of retinopathy of prematurity (ROP) in premature infants. Methods: This retrospective cohort study evaluated the data of 1985 idiopathic premature infants who underwent ROP screening from 2016 to 2022. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two subgroups based on the presence of proliferation. Comparisons were made concerning the serum multiple of the median values of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and alpha-fetoprotein (AFP) among aneuploidy screening biomarkers. Results: While 1628 premature infants were in the non-ROP group, 357 were in the ROP group. Of the infants with ROP, 72 were in the proliferative ROP group and 285 in the non-proliferative ROP group. There was no significant difference in the multiple of the median values of the evaluated serum biomarkers (uE3, hCG, and AFP) between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion: The multiple of the median values of second-trimester aneuploidy screening serum biomarkers were not able to predict the development of ROP in premature infants. This result may have been caused by the fact that the blood tests were taken only once and in the same weeks.

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The Possible Role Serum Biochemical Analysis Can Play in Predicting an Infant’s Risk of Retinopathy of Prematurity; Elevated Serum Magnesium

Akdogan¹,

Sabaner²,

Üstündağ³

et al. 2019

JBM

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Purpose: We evaluated biochemical analysis results with the aim of discovering serum levels that have possible effects on the development of retinopathy of prematurity (ROP). Methods: A retrospective study was conducted between January 2017 and January 2018 on a total of 110 infants with 35 or less gestational weeks. The sample included 78 infants who had been diagnosed with different stages of ROP and 32 infants without ROP. Results from routine serum biochemical analyses, performed at birth and at one month after birth, were evaluated. The Independent Sample t-test and Mann-Whitney U test were performed to compare the data. Results: The infants with ROP were born at a mean of 28.0 (±2.1) weeks of gestation, weighing a mean of 1066 (±314) g, and the mean duration of stay in the incubator was 38.2 (±19) days. The infants without ROP were born at a mean of 29.6 (±2.6) weeks of gestation, weighing a mean of 1265 (±372) g. 59 infants (53.6%) were females, and 51 (46.4%) were males. Between infants with and without ROP, differences in the following levels were not statistically significant: glucose, blood urine nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, albumin, total protein, direct bilirubin, indirect bilirubin, uric acid, and phosphorus. Serum magnesium (Mg) levels at birth in infants with ROP were significantly higher than infants without ROP (p = 0.014). Conclusions: Serum Mg levels at birth were found to be higher in infants with ROP than in those without ROP. The levels may be dependent on the mothers' treatment of Mg for different medical reasons.

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Results of Screening for Retinopathy of Prematurity: How the Ideal Screening Program Should Be?

Cited by 4 publications

References 4 publications

Impact of Platelet Count in Retinopathy of Prematurity

Impact of Platelet Count in Retinopathy of Prematurity

Can Serum Biomarker Values from Second-Trimester Aneuploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants?

The Possible Role Serum Biochemical Analysis Can Play in Predicting an Infant’s Risk of Retinopathy of Prematurity; Elevated Serum Magnesium

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