Do Nano‐crystalline Silver‐Coated Hernia Grafts Reduce Infection?

Adıgüzel, Elif Nergiz; Esen, Ebru; Aylaz, Gökçe; Yağız, Betül Keskinkılıç; Kıyan, Mehmet; Doğan, Aydın; Ünal, Ali Ekrem

doi:10.1007/s00268-018-4661-3

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…An in vivo study regarding the efficacy of nanocrystalline silver-coated PP meshes against methicillin-resistant Staphylococcus aureus (MRSA)-induced infection in a rat model showed a significantly better bactericidal effect than the non-coated PP device [50].…”

Section: Surgical Meshes With Antimicrobial Metalsmentioning

confidence: 99%

Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives

Mirel

Pusta

Moldovan³

et al. 2022

JCM

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Recent advances in the development of biomaterials have given rise to new options for surgery. New-generation medical devices can control chemical breakdown and resorption, prevent post-operative adhesion, and stimulate tissue regeneration. For the fabrication of medical devices, numerous biomaterials can be employed, including non-degradable biomaterials (silicone, polypropylene, expanded polytetrafluoroethylene) or biodegradable polymers, including implants and three-dimensional scaffolds for tissue engineering, which require particular physicochemical and biological properties. Based on the combination of new generation technologies and cell-based therapies, the biocompatible and bioactive properties of some of these medical products can lead to progress in the repair of injured or harmed tissue and in tissue regeneration. An important aspect in the use of these prosthetic devices is the associated infection risk, due to the medical complications and socio-economic impact. This paper provides the latest achievements in the field of antimicrobial surgical meshes for hernia repair and discusses the perspectives in the development of these innovative biomaterials.

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Section: Surgical Meshes With Antimicrobial Metalsmentioning

confidence: 99%

Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives

Mirel

Pusta

Moldovan³

et al. 2022

JCM

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“…This study analysed the most common titanium-coated PP meshes including TiMesh produced by plasma coating of atomic titanium and BioCer with a coating of TiO2. Reticular meshes made of PP with a coating of nano-crystalline silver (Optilene Silver Mesh ® from Braun) provide the only antimicrobial mesh currently used in clinics [122]. Regarding the laminar meshes, in a prospective study with 86 patients having incisional or ventral hernias who used laminar Gore-Tex ® mesh in laparoscopic repairs, an average hospital stay of 4.8 days was achieved [123].…”

Section: 1non-bioabsorbable Meshesmentioning

confidence: 99%

“…Polypropylene meshes with a silica/silver layer have been proposed for hernia repair and showed good biocompatibility in peritoneal mesothelial cells and tissue repair [244]. An antimicrobial mesh made of PP (Optilene Silver Mesh ® from Braun) with a coating of nano-crystalline silver showed significantly better bactericidal effect than the normal PP meshes [122]. Other metal-based meshes impregnating with Zinc (ZnMesh) have recently been proposed for abdominal wall repair and showed significant reduction of infection in a rat animal peritonitis model [245].…”

Section: Meshes With Antimicrobial Metalsmentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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“…Nanosilver (NS) as one type of excellent antibacterial agent has strong and broad-spectrum antiviral activity against both Gram-positive and -negative bacteria, including multiple drug tolerance bacteria, for example, methicillin-resistant Staphylococcus aureus (MRSA) ( 11 ). What is more, there is some proposal that NS suppressed bacteria via various mechanisms, such as cell membrane destruction, DNA replication interference, and respiratory function inhibition without causing drug resistance ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Silver Nanoparticles With Thermoplastic Polyurethane on Postoperative Rehabilitation of Diabetic Patients With Open Fracture of Lower Extremities

Zhang

Yao

et al. 2022

Front. Surg.

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ObjectiveThis retrospective study aims to explore the effect of silver nanoparticles with thermoplastic polyurethane (TPU/NS) on the rehabilitation of diabetic patients with open fracture of lower extremities.MethodsDiabetic patients (n = 98) with open fracture of lower extremities treated in our hospital were analyzed retrospectively from June 2015 to December 2021. TPU/NS nanocomposites were prepared for postoperative treatment of diabetic patients with open fracture of lower extremities. First, the cultured Staphylococcus aureus and Escherichia coli were used to test the antibacterial effect of TPU/NS dressing in vitro. After using TPU/NS dressing (observation group) and traditional dressing (control group), the inflammatory reaction, clinical treatment, functional rehabilitation, and adverse reactions in patients were compared.ResultsTPU/NS dressing effectively inhibited the growth of bacteria with a minimum inhibitory concentration of 2 μg/mL. The usage of TPU/NS dressing reduced the inflammatory reaction by reducing positive rate of bacteria after the dressing on the seventh day postoperatively. Besides, the times of dressing, stopping time of wound exudation, wound healing time, length of hospital stay, and VAS score in the observation group were lower than those in the control group; the incidence of adverse reactions after treatment was lower in the observation group as compared with the control group (17.07% vs. 35.09%). Meanwhile, the functional rehabilitation and life quality of patients in the observation group were better TPU/NS dressing treatment.ConclusionTPU/NS dressing has the function of promoting the postoperative recovery of patients by inhibiting the bacterial infection of the wound, thus improving the limb function and life quality. As a result, there was a tremendous potential to apply the constructed TPU/NS membrane to diabetic patients with open fractures, especially those with soft tissue injury.

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Do Nano‐crystalline Silver‐Coated Hernia Grafts Reduce Infection?

Cited by 10 publications

References 27 publications

Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives

Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Effect of Silver Nanoparticles With Thermoplastic Polyurethane on Postoperative Rehabilitation of Diabetic Patients With Open Fracture of Lower Extremities

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