Effect of Silver Nanoparticles With Thermoplastic Polyurethane on Postoperative Rehabilitation of Diabetic Patients With Open Fracture of Lower Extremities

Zhang, Dong; Yao, Dongchen; Ma, Ruofei; Nan, Shaokui; Li, You; Zhu, Yanyan; Zhu, Shiwei

doi:10.3389/fsurg.2022.954155

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…The use of silver nanoparticles with thermoplastic polyurethane dressings among diabetic patients with open fractures significantly reduced bacteria colonization (4.88% vs. 12.28%), wound healing time, and hospitalization period [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…SCX-powder patented complex, including: silicon dioxide 75.0-85.0%; chlorhexidine 15.4-25.14%; silver 0.14-0.4% Reference [15] any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work.…”

Section: Quantity (%) Functionmentioning

confidence: 99%

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Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Pathi,

Mishra,

Moharana

et al. 2024

Cureus

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Background: Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence of antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance and wound healing. This study aimed to document the efficacy of a topical silver nanoparticle-based cream on bacteria clearance and wound healing in infected wounds compared to Mupirocin.Methods: This open-label parallel randomized clinical trial allocated 86 participants with infected wounds (culture-positive) into Kadermin, silver nanoparticle-based cream arm (n=43) and Mupirocin arm (n=43) and documented the swab culture on day 5 and wound healing at day 28, along with periodic wound status using the Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics and other medications for underlying diseases. The intention-to-treat principle was adopted for data analysis using the chi-square and Student t tests to document the differences between groups according to variable characteristics.Results: All participants completed the follow-up. On day 5, wound bacteria clearance was observed in 86% and 65.1% of the participants in the Kadermin and Mupirocin arms, respectively (p=0.023). At day 28, complete wound healing was observed in 81.4% and 37.2% of the participants in the Kadermin and Mupirocin arms, respectively (p≤0.001). No local or systemic adverse event or local reaction was observed in any of the participants. Conclusion: Kadermin, the silver nanoparticle-based cream, has better efficacy in achieving faster wound bacteria clearance and healing in infected wounds compared to Mupirocin. This may have relevance for its use as an antibiotic-sparing agent in wound management.

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Section: Discussionmentioning

confidence: 99%

Section: Quantity (%) Functionmentioning

confidence: 99%

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Pathi,

Mishra,

Moharana

et al. 2024

Cureus

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“…According to Bolton et al, 25 silver ions can bind to negatively charged bacteria, increase the permeability of the bacterial outer membrane, and induce bacterial apoptosis. The results of a study by Zhang et al 26 in China, entitled “Examining the effect of silver nanoparticles with thermoplastic polyurethane on postoperative rehabilitation of diabetic patients with lower limb open fracture” demonstrated that the use of this combination can both reduce the inflammation and unwanted reactions and lead to the wound healing by inhibiting the bacterial infection of the wound. Lázaro Martinez et al 19 suggested in their study that the silver ion dressings can continuously and effectively release silver ions, destroy the bacteria around the diabetic foot ulcer, improve the wound healing environment, and can also hydrate and soften necrotic tissues and clean the wound, and thereby, contribute to the wound infection reduction.…”

Section: Discussionmentioning

confidence: 99%

Examining the effect of polyurethane dressing containing silver particles on the rate of diabetic foot ulcer infection in hospitalized patients: A randomized control study

Hosseinpoor,

Kalroozi,

Nezamzadeh

et al. 2023

Health Science Reports

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Background and AimsOne of the new types of dressings is the polyurethane dressing containing silver particles. This study was designed to evaluate the effect of polyurethane dressing containing silver particles on the rate of diabetic foot ulcer infection in hospitalized patients in a military hospital.MethodsThis was a randomized clinical trial study on 48 patients with diabetic foot ulcers who were referred to the wound clinic of Shahid Dr. Chamran Hospital in 2022. The qualified samples were divided into two groups of silver polyurethane dressing and simple sterile dressing based on a randomization block method. The wounds of both groups of patients were initially cleaned with normal saline and in the first round of dressing, and a sample of tissue secretions was collected by the researcher using a sterile swab from the wounds of the patients on two occasions, superficially and deeply. The patients' wounds in the intervention group were dressed with polyurethane foam dressing containing silver particles, while the simple sterile routine dressing was used in the control group. The rate of infection and wound secretions were examined and recorded on the first, seventh, fourteenth, and twenty‐first days from the start of dressing in both groups. To collect data, the IDSA tool was used.ResultsThe rates of wound infection before the intervention showed no significant differences in the two groups (p = 0.242). However, these rates changed on the 7th, 14th, and 21st days after the intervention. Moreover, the infection rate was significantly lower in the polyurethane dressing group containing silver particles (p < 0.001 and F = 30.31).ConclusionsUsing polyurethane dressing was proven to be more effective in this study on the rate of diabetic ulcer infection in patients compared to the simple sterile dressing. Thus, nurses can use this dressing for faster treatment of diabetic foot ulcers infection.

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“…Zhang et al [ 94 ] conducted a study in which they explored the effectiveness of thermoplastic polyurethane dressings containing silver nanoparticles (TBU/NS) used in the treatment of open fractures in diabetic patients. TBU/NS dressing was used as a part of postoperative treatment, in the therapy of open fractures of the lower extremities.…”

Section: Clinical Application Of Wound Dressings Containing Silver An...mentioning

confidence: 99%

Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing—From Experimental Studies to Clinical Practice

Rybka

Mazurek

Konop

2022

Life

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Impaired wound healing affects hundreds of million people around the world; therefore, chronic wounds are a major problem not only for the patient, but also for already overloaded healthcare systems. Chronic wounds are always very susceptible to infections. Billions of dollars are spent to discover new antibiotics as quickly as possible; however, bacterial resistance against antibiotics is rising even faster. For this reason, a complete shift of the antibacterial treatment paradigm is necessary. The development of technology has allowed us to rediscover well-known agents presenting antimicrobial properties with a better outcome. In this context, silver nanoparticles are a promising candidate for use in such therapy. Silver has many useful properties that can be used in the treatment of chronic wounds, such as anti-bacterial, anti-inflammatory, and anti-oxidative properties. In the form of nanoparticles, silver agents can work even more effectively and can be more easily incorporated into various dressings. Silver-based dressings are already commercially available; however, innovative combinations are still being discovered and very promising results have been described. In this review article, the authors focused on describing experimental and clinical studies exploring dressings containing either silver or silver nanoparticles, the results of which have been published in recent years.

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Effect of Silver Nanoparticles With Thermoplastic Polyurethane on Postoperative Rehabilitation of Diabetic Patients With Open Fracture of Lower Extremities

Cited by 4 publications

References 31 publications

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Examining the effect of polyurethane dressing containing silver particles on the rate of diabetic foot ulcer infection in hospitalized patients: A randomized control study

Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing—From Experimental Studies to Clinical Practice

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