Background: Detection of paroxysmal atrial fibrillation (PAF) in acute ischemic stroke patients poses diagnostic challenge. The aim of this study was to predict the presence of PAF by means of 12-lead ECG in patients with acute ischemic stroke. Our hypothesis was that P-wave dispersion (Pd) might be a useful marker in predicting PAF in patients with acute ischemic stroke.Methods: 12-lead resting ECGs, 24-hour Holter recordings and echocardiograms of 400 patients were analyzed retrospectively. PAF was detected in 40 patients on 24-hour Holter monitoring. Forty out of 360 age and gender matched patients without PAF were randomly chosen and assigned as the control group. Demographics, P-wave characteristics and echocardiographic findings of the patients with and without PAF were compared.Results: Maximum P-wave duration (p=0.002), Pd (p<0.001) and left atrium diameter (p=0.04) were significantly higher in patients with PAF when compared to patients without PAF. However, in binary logistic regression analysis Pd was the only independent predictor of PAF. The cut-off value of Pd for the detection of PAF was 57.5 milliseconds (msc). Area under the curve was 0.80 (p<0.001). On a single 12-lead ECG, a value higher than 57.5 msc predicted the presence of PAF with a sensitivity of 80% and a specificity of 73%.Conclusion: Pd on a single 12-lead ECG obtained within 24 hours of an acute ischemic stroke might help to predict PAF and reduce the risk of recurrent strokes.
Large scale quantum computing motivates the invention of two-qubit gate schemes that not only maximize the gate fidelity but also draw minimal resources. In the case of superconducting qubits, the weak anharmonicity of transmons imposes profound constraints on the gate design, leading to increased complexity of devices and control protocols. Here we demonstrate a resource-efficient control over the interaction of strongly-anharmonic fluxonium qubits. Namely, applying an offresonant drive to non-computational transitions in a pair of capacitively-coupled fluxoniums induces a ZZ-interaction due to unequal ac-Stark shifts of the computational levels. With a continuous choice of frequency and amplitude, the drive can either cancel the static ZZ-term or increase it by an order of magnitude to enable a controlled-phase (CP) gate with an arbitrary programmed phase shift. The cross-entropy benchmarking of these non-Clifford operations yields a sub 1% error, limited solely by incoherent processes. Our result demonstrates the advantages of strongly-anharmonic circuits over transmons in designing the next generation of quantum processors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.