Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: A prospective study ın adult and elderly patients with newly diagnosed partial epilepsy

Doğan, Ebru Apaydın; Usta, Burcu Ekmekci; Bilgen, Rengin; Şenol, Yeşim; Aktekin, Berrin

doi:10.1016/j.yebeh.2008.02.001

Cited by 53 publications

(23 citation statements)

References 21 publications

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“…11,12,15,20 It also has been suggested that elderly patients on concomitant natriuretic drugs is at significant risk of developing serum sodium levels below 135 mEq/L. 11 Our study did not show a significant correlation between age or diuretic use and hyponatremia.…”

Section: Discussioncontrasting

confidence: 41%

Risk Factors of Oxcarbazepine-Induced Hyponatremia in Patients With Epilepsy

Lin

Wang

et al. 2010

Clinical Neuropharmacology

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Higher dosages of OXC and the number of combination antiepileptic drugs may increase the risk of OXC-induced hyponatremia in patients with epilepsy. Most patients are asymptomatic, but if symptoms of hyponatremia, such as headache, general malaise, gait disturbance, and somnolence, are suspected, the serum sodium level should be measured; it may be necessary to decrease the OXC dose or to discontinue the drug.

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Section: Discussioncontrasting

confidence: 41%

Risk Factors of Oxcarbazepine-Induced Hyponatremia in Patients With Epilepsy

Lin

Wang

et al. 2010

Clinical Neuropharmacology

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“…28,32 OXC is considered a well-tolerated aromatic AED with a much lower incidence of SJS/TEN than CBZ. 33,34 OXC and ESL are rapidly and extensively metabolized to LIC in the human body. 35,36 In Taiwan SJS/TEN attributed to CBZ and OXC was estimated to be one in 2,000 and 10,000 exposures, respectively.…”

Section: Discussionmentioning

confidence: 99%

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome

Wei

Chung

Huang

et al. 2012

Journal of Allergy and Clinical Immunology

266

238

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“…This hypothesis could be supported by the observation that the incidences of hypersensitivity reactions caused by these 2 drugs were different, and SJS/TEN cases caused by OXC were reported to be fewer than those caused by CBZ. [37][38][39] Global analysis of TCR repertoires in patients with OXC-induced hypersensitivity in the future will provide a piece of important information to clarify the contribution of T cells in cross-reactivity between CBZ and OXC.…”

Section: Discussionmentioning

confidence: 99%