Antibacterial photodynamic therapy is a promising method of treating local infected foci, especially surgical and burn wounds, trophic and diabetic ulcers. This work explores the photophysical and antibacterial properties of novel phthalocyanine- and synthetic-bacteriochlorin-based octacationic photosensitizers (PS). The results of the study confirm their low degree of aggregation at high concentrations, as well as high efficiency of photodynamic treatment of Gram-negative bacterial biofilms.

No abstract

The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases.This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra-and octabacteriochlorins (ZnPcChol 8 , (3-PyBrE) 4 BCBr 4 and (3-PyEPy) 4 BCBr 8 ). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.

No abstract

The aim of this work is the study of antibacterial photodynamic inactivation (APDI) of Escherichia coli (on the example of a model E. coli K12 TG1), the influence of the charge of photosensitizer (PS) molecules on the efficiency of binding with these Gram-negative bacteria. The results obtained confirm that PSs based on polycationic phthalocyanines and synthetic bacteriochlorins provide effective photodynamic inactivation of E. coli, much higher than monocationic methylene blue and electro-neutral bacteriochlorin derivative. The efficiency of APDI, assessed by the intensity of bioluminescence of model E. coli K12 TG1 bacteria, correlates with the charge of PS molecules and the efficiency of electrostatic binding of PS to bacterial cells.

Antibacterial photodynamic therapy is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Both Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Pseudomonas aeruginosa are found in most infected wounds. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without developing resistance in response to treatment. This work is dedicated to the study of photophysical and antibacterial properties of new photosensitizers based on tetracationic synthetic bacteriochlorins with a reduced size of the molecule and molecular weight for PDI of S. aureus and P. aeruginosa bacteria and their biofilms.

No abstract

No abstract