New cationic photosensitizers: photophysical properties and results of preliminary studies of antibacterial efficacy

Akhlyustina, E. V.; Меерович, Г. А.; Тиганова, И. Г.; Макарова, Е. А.; Philipova, N. I.; Romanishkin, I.D.; Алексеева, Н. В.; Luk’yanets, E. A.; Romanova, Yu. M.; Loschenov, Victor B.

doi:10.1088/1742-6596/1189/1/012033

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases, aPDTis used in the treatment of superficial injuries of the skin and soft tissues (purulent wounds, burns, trophic ulcers). As a result of such therapy, complete destruction of bacterial cells without the development of resistance to aPDT occurs [1]. Photosensitizers (PS), generating singlet oxygen( 1 O 2 )-an active oxidizing agent-upon excitation with light, are successfully used in photodynamic therapy (PDT) of diseases of various etiologies [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

et al. 2021

View full text Add to dashboard Cite

In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

et al. 2021

View full text Add to dashboard Cite

show abstract

Influence of acetic acid on the photocatalytic activity of photosensitiser–amphiphilic polymer complexes in the oxidation reaction of tryptophan

Kardumyan

Aksenova

Глаголев

et al. 2020

The Journal of Chemical Physics

View full text Add to dashboard Cite

The effect of acetic acid on the photosensitizing activity of dimegin (DMG), chlorin e6 (Ce6), and their complexes with amphiphilic polymers—Pluronic F-127 and poly-N-vinylpyrrolidone (PVP)—in the model reaction of tryptophan photo-oxidation has been established. It was shown that the photocatalytic activity of photosensitizers (PS), which is characterized by the effective constant of the tryptophan photo-oxidation rate (keff), increases by 1.4 times for DMG, while for Ce6, it decreases by 1.2 times in a weak acidic medium (pH ∼ 4). The influence of acetic acid on the effective constant keff of the tryptophan photo-oxidation rate in the presence of PS–amphiphilic polymer complexes is determined by the nature of the polymer. Thus, the photocatalytic activity of the PS–F127 system decreases at pH ∼ 4.0, and the photocatalytic activity of PS–PVP complexes is insensitive to the presence of acetic acid in the medium. It has been suggested that the observed effects in the PS–F127 system in a weak acidic medium (pH ∼ 4) are associated with the influence of acetic acid on the supramolecular structure of Pluronic F127.

show abstract

New cationic photosensitizers: photophysical properties and results of preliminary studies of antibacterial efficacy

Cited by 2 publications

References 18 publications

Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

Influence of acetic acid on the photocatalytic activity of photosensitiser–amphiphilic polymer complexes in the oxidation reaction of tryptophan

Contact Info

Product

Resources

About