Diabetes mellitus (DM) is a global medical and social problem, its prevalence is steadily increasing throughout the world. The significance of DM is due to early disability and high mortality, primarily from macro- and microvascular complications of diabetes mellitus. Adequate therapy and its timely intensification in order to achieve an optimal individual level of glycemic control is an important aspect in this regard. Insulin therapy is indicated for all patients with type 1 diabetes mellitus. In type 2 diabetes the appointment of basal insulin is necessary if it is impossible to adequately control glycemia with oral drugs. Treatment of diabetes all over the world and in our country requires significant healthcare costs. The problem of reducing the cost of drug therapy in all countries of the world is currently being solved by the admission to the market of biosimilar drugs (biosimilars). A biosimilar (biosimilar) medicinal product (biosimilar, biosimilar) is a biological product similar in terms of quality, efficacy and safety to a reference biological medicinal product in the same dosage form and having an identical route of administration. Insulin glargine is one of the commonly used drugs in clinical practice and is of interest for reproduction. Biosimilar currently registered. This is a biosimilar of domestic production of insulin glargine with proven bio- and therapeutic equivalence, immune safety, good tolerance, recognized as interchangeable with the original insulin glargine. Indications and contraindications for use can be extrapolated to biosimilar without fear of reducing efficacy and the development of adverse events.
Introduction. Proper education of patients and their environment is essential in achieving compensation for type 1 diabetes mellitus (T1DM).Aim. Identifying problems in T1DM management in children and adolescents in daily life and assessing the needs for educational activities for children and parents.Materials and methods. A sociological survey with the participation of 508 parents of children and adolescents with T1DM was conducted in February-April 2022 in 7 federal districts of the Russian Federation. The electronic questionnaire contained 80 questions on various areas of disease management.Results. Age of children from 3 to 18 years (average 10.7 ± 3.64 g); gender of children female – 52.2% (265), male – 47.8% (243); T1DM experience – from 1 month to 15 years (average 3.9 ± 3.2 years). Parents face problems of glycemic variability in children (19.5%), difficulties in adjusting insulin dosages (14.4%), catering in schools/kindergartens (21.0%), preferential provision of insulins and medical devices for self-control of glycemia (17.1%), age characteristics of childhood and adolescence (14.9%), psychological problems (24.4%), indifference of medical workers (10.8%), difficulties of examination for glycated hemoglobin (36.3%); low physical activity of children (57.9%), lack of knowledge and skills of proper monitoring of glycemia during physical activity (46.6%), inaccessibility of sports (22.7%). Parents receive knowledge in schools of diabetes (37.6%), from endocrinologists (42.5%), dia chats in instant messengers (70.5%), social networks (59.6%), Internet resources (77.2%) are considered an important source of information. 91.3% of parents need constant replenishment of knowledge, they consider it important to educate children and form a responsible attitude towards their health.Conclusion. The current continuing education of patients with T1DM and their environment in the management of the disease in everyday life, the solution of issues of timely and full preferential provision of children and adolescents with T1DM medical devices for monitoring glycemia and insulin preparations will contribute to increasing the effectiveness of therapy, reducing the risk of complications and improving their quality of life.
This article analyzed the relationship between sexual activity and the structural and functional state of the prostate gland. The biomechanism of hormonal effects during sexual activity was evaluated. The influence of hormones on the functioning of the prostate gland was analyzed. It has been established that constant sexual activity in moderate amounts reduces the risk of developing prostate diseases and is an important method of prevention. To correct copulative function disorders in diseases of the prostate gland, it is advisable to use prostatic peptides that have an organotropic effect.
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