Administration of large doses of L-lysine monohydrochloride at meal times has proved to be an efficient method, free of significant side effects, for the production of a hyperchloremic acidosis to restore responsiveness to mercurial diuretics in cardiac and cirrhotic patients with refractory fluid retention. Results obtained in a group of 14 patients are presented and advantages of L-lysine monohydrochloride over previously available acidifying chloride salts are discussed.
Rapid alteration of plasma, electrolyte concentrations during dialysis with the artificial kidney may be associated with changes in the electrocardiogram and in cardiac function. In this study, the electrocardiographic changes encountered during 33 hemodialyses are described and correlated with abnormal electrolyte patterns and their correction.
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