Cyclical edema and shock due to increased capillary permeability

Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary thermodilution technique for volume management

“…Laboratory findings include hemoconcentration, hypoproteinemia and a monoclonal gammopathy [2]. SCLS was first described in 1960 by Clarkson et al [1]. The median age for the first SCLS-manifestation is 46 years with no sex-related difference [3].…”

Severe cerebral involvement due to idiopathic systemic capillary leak syndrome

“…Idiopathic systemic capillary leak syndrome (ISCLS) is a rare and life‐threatening disorder first described by Clarkson and is characterized by recurrent attacks of hypotension, hypoalbuminemia, and hemoconcentration 1, 2, 3. The cause of ISCLS is unknown.…”

“…A diagnosis of idiopathic systemic capillary leak syndrome (ISCLS) was made because of recurrent attacks of generalized edema, hypotension, hypoalbuminemia, and hemoconcentration and a concomitant monoclonal gammopathy, which has been reported in the vast majority of patients 1, 2.…”

Idiopathic Systemic Capillary Leak Syndrome Preceding Diagnosis of Infiltrating Lobular Carcinoma of the Breast With Quiescence During Neoadjuvant Chemotherapy

“…[1][2][3][4][5][6] The shock that patients with SCLS experience, with associated hemoconcentration and hypoalbuminemia, is caused by sudden, massive leakage of proteins and serum into the extravascular space. 1,7 Plasma proteins up to 200 kDa or, in some cases, 900 kDa escape the capillary bed, resulting in an intravascular loss of up to 70% of plasma volume.…”