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Administration of large doses of L-lysine monohydrochloride at meal times has proved to be an efficient method, free of significant side effects, for the production of a hyperchloremic acidosis to restore responsiveness to mercurial diuretics in cardiac and cirrhotic patients with refractory fluid retention. Results obtained in a group of 14 patients are presented and advantages of L-lysine monohydrochloride over previously available acidifying chloride salts are discussed.

The effects of mare than sixty analogues of thyroxine have been investigated in animals, and more than thirty analogues have been studied in humans. Animal studies have shown that structural alterations of the thyroid hormone cause not only large variations in potency but also dissociation of the various hormonal effects of thyroxine. Dissociation of thyroid horrrwnal effects has also been demonstrated in the human with triiodothyropropionic acid. The drug is satisfactory as maintenance therapy in myxedema and appears to have definite advantages in maintaining the myxedematous patient with angina pectoris. Triiodothyropropionic acid effects a 15 to 20 per cent drop in the serum cholesterol of about 80 per cent of euthyroid individuals with either elevated or normal cholesterol levels. Its administration in the proper dosage decreases elevated serum uric acid levels in both myxedematous and euthyroid individuals.

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