Nach l3eobachtungen von H e il e r u. Mitarb. führen hohe Testosterondosen im menschlichen Hoden zunächst zu einer Unterdrückung der Spermiogenese, die jedoch später wieder H e j n k e u. T o n u t t j: Wirkung des Testosterons auf die spermiogenetisdie ÄktlVtt des Hodens Dtsch. med. Wsthx;, 81.3g.
Zusammenfassung
2 %ige Miconazol‐Creme zeigte eine ausgezeichnete Wirkung bei der Behandlung von Dermatophyten einschließlich Candida‐Infektionen und bakteriellen Erkrankungen der Haut, der Nägel und Schleimhäute, und hier insbesondere bei Soor‐Vaginitis an 248 Patienten.
Hervorgehoben werden hier die Behandlungserfolge bei Tinea unguium (31 Patienten) und Paronychia candidamycetica (22 Patienten) mittels Okklusivverbände mit 2 %iger Miconazol‐Creme.
Die Verträglichkeit von Miconazol ist ausgezeichnet, wie ein spezieller Testversuch an 46 Patienten und die umfangreiche klinische Anwendung an insgesamt 248 Patienten ausweisen.
Summary
2% Miconazol cream was found to have an excellent effect in treatment of dermatophyte (including Candida) infections and bacterial diseases of the skin, nails and mucosae, especially Candida vaginitis, in 248 patients.
Special reference is made to the results obtained in tinea unguium (31 patients) and paronychia candidamycetica (22 patients) with occlusive dressings with 2% Miconazol cream.
Tolerance is excellent, as shown by special tests in 46 patients and a large‐scale clinical trial in 248 patients.
Resumen
La crema de Miconazol al 2% mostró una excelente acción en el tratamiento de dermatofitosis, incluyendo infecciones por Candida y bacterias de la piel, uñas y mucosas, aquí especialmente en candidosis vaginal, en 248 pacientes. Se resaltan los éxitos terapéuticos en tinea unguium (31 pacientes) y paroniquia candidamicética (22 pacientes) por medio de vendajes oclusivos nocturnos con crema de Miconazol al 2%. La tolerancia de Miconazol es muy buena, como mostró un test especial en 46 pacientes y la aplicación terapéutica en un total de 248 pacientes.
The increasing prevalence of gonorrhoea has accentuated the need for a serological diagnostic test, particularly in women with chronic or latent infections in whom cultural methods are unsatisfactory. However, a diagnostic test, to be useful, must be also highly specific and in the gonococcal field the general rule holds that increasing sensitivity is associated with decreasing specificity. While the choice of method is largely based on practical convenience, the appropriate specificity can be achieved only by finding suitable antigens. It is the search for these which is now occupying most workers. Results in our laboratories have shown that the choice of the gonococcal strains from which to prepare the antigen is extremely important. The overall results were considered very good, the total cure rate being 98-1 per cent.
Influence of Gonococcal Urethritis inThe success of the treatment in ten patients with gonorrhoeal epididymitis was outstanding; six patients received 2 5 g. and four received 1-5 g. thiamphenicol orally for 5 or 6 days, and all were cured.The results of treatment of seventeen patients with non-specific urethritis (1-5 g. thiamphenicol daily for 5 to 8 days) were also good; fifteen patients remained free of relapse. Serial smears and cultures for gonococci showed that the bacteriostatic effect on Neisseria gonorrhoeae of 2 5 g. thiamphenicol in a single oral dose began between the second and third hours after administration.With a single dose (2-5 g.) and repeated doses (1-5 g. daily for 6 days) of thiamphenicol, no change in the peripheral blood picture could be demonstrated even after months. With the same dosage and conditions, no effect on spermatogenesis was observed.Serial darkfield examinations of material from primary chancres showed that Treponema pallidum disappeared at the latest 72 hours after a single dose of 2 5 g. thiamphenicol, and the Herxheimer reaction did not occur after a subsequent injection of penicillin.The tolerance of thiamphenicol in the form we used was excellent. Allergies and other side-effects such as gastric disturbances and vomiting were not observed.
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