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Preventing male infertility by marjoram and sage essential oils through modulating testicular lipid accumulation and androgens biosynthesis disruption in a rat model of dietary obesity, Egyptian

In this study, the labeling method of levofloxacin with technetium-99m and its biological evaluation were described.99m Tc-L-Flox was synthesized via direct complexation with technetium-99m in the presence of stannous chloride dihydrate as reducing agent. The optimum amounts of the reactants are: 1-2 mg levofloxacin, 150 mg stannous chloride dihydrate and 48-1490 MBq pertechnetate. The reaction mixture was bring to pH 6 and kept at room temperature for 30 min. The labeled levofloxacin was stable for more than 8 h. The in vivo evaluation of 99m Tc-L-Flox in man-induced inflammation models showed that this tracer was localized with different values. The live E. Coli model had the highest value which was 2.9%, the heat killed E. coli model had a value of 2.0%, and the turpentine oil model had a value of 1.2% at 24 post injection, while the non-inflamed muscle had activity of 0.5%. All the gathered biological data support the usefulness of 99m Tc-L-Flox as infection imaging agent. The freeze-dried form of Sn-L-Flox was prepared and found meet all the radiochemical and biological tests.

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Radioiodination of meta-iodobenzylguanidine (MIBG) by the isotopic exchange technique in the dry state has been performed. Benzoic acid, pivalic acid and acetamide have been used as molten protic media to promote isotopic exchange reactions. Ammonium sulphate, diammonium hydrogen ortho-phosphate and ammonium chloride were used as catalysts which provide acidic media to facilitate exchange reactions. Maximum radiochemical yields of 97.1+1.3% and 84.3+1.6% [1311] MIBG were obtained when ammonium sulphate and benzoic acid were used. High radiochemical yields of 88.3+1.1% and 74.4+1.5% 11311] MIBG were also obtained in case of diammonium hydrogen orthophosphate and pivalic acid which suggests their successful use as reaction media in the radioiodination of MIBG. The activation energy for the exchange reaction in ammonium sulphate was calculated to be 10.8 kcal/mole.