Age-friendly college campuses offer opportunities for lifelong learning for students of all ages. University-based retirement communities are especially well aligned with this goal by allowing residents to enroll in college courses. Although this arrangement is a standard educational option for college-linked communities, it can have challenges. In particular, the semester-long schedule may be inconvenient for many older students. The Talk of Ages intergenerational module program described in this case study was designed to offer an alternative curricular format to bring older and younger students together for 1 to 2 weeks in focused course activities. To encourage participation across the curriculum, instructors were urged to draw on existing course content. Initial feedback about the program indicated that instructors as well as older and younger students found the program appealing. Useful suggestions for refining the program were also revealed.
Ulcerative colitis is a chronic disease having a regressive nature. Commonly used diagnostic methods have the disadvantage to be invasive, time-consuming, and expensive. Therefore, a new sensitive method for the detection and monitoring of disease activity is urgently needed in clinical practice. In the current investigation, radio complexation of olsalazine with technetium-99m, its characterization, and optimization of the labeling conditions were explored. Optimum radiochemical yield of (99m) Tc-olsalazine (97.6% ± 1.8%) was obtained via direct complexation with technetium-99m (~200 MBq) in the presence of stannous chloride dihydrate (100 µg) as reducing agent at pH 6. It was observed that the complex showed significant in vitro stability in serum at 37°C for more than 11 h. The computer-generated optimized geometries of the (99m) Tc-olsalazine were reported, and biodistribution studies were carried out using chemically and microbiologically mice-induced ulcerative colitis models. The tracer showed a good localization in both models and was excreted mainly via liver and to some extent via kidney. Imaging can be performed at 1-2 h post-injection; at that time, the background activity has cleared, and the activity is concentrated in the target site. All the gathered biological data supported the usefulness of (99m) Tc-olsalazine as a potential imaging agent for ulcerative colitis.
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