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376 CHLOROMYCETIN, STREPTOMYCIN, IN TISSUE CULTUREanalysis of the feces revealed no dye. This is not surprising since its presence in the stool requires a patent biliary system. I n regard to renal excretion, Table I1 shows that in both species studied, less than 55% of the administered dye appeared in the urine.Discussion. I t is apparent that the results obtained in dogs and rats with regurgitation jaundice differ significantly from similar observations in human subjects( 1 ) . The rapidity with which RSP disappears from the serum of these animals suggests that other mechanisms are present for removal of dye in the absence \of hepatic escretory function.Cohn. Levine and Streicher showed that BSP is removed from the serum of the hepatectoniized dog( 7 ) . Our data indicate that the dye is similarly removed when normal hepatic pathways are blocked. These data, however. are not applicable to BSP removal in man ( 1 .S ) . I t has been stated that the kidney is able to excrete significant amounts of BSP when the serum concentration remains elevated for prolonged periods( 9). In our experiments, 30-50% of the amount of dye given was recovered in the urine. Mechanisms of removal or destruction other than renal, therefore, probably play a role when the dye is not completely excreted through normal channels. In this connection, Brauer and coworkers have demonstrated that BSP may be chemically altered by the liver (10,ll).Summary. I n dogs and rats with complete biliary obstruction, the retention of BSP in the serum was of much shorter duration than that previously observed in man. Conclusions concerning mechanisms of BSP removal in man based on observations made in the d,og must be questioned in the light of these data.

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