Coombs Type of Antibodies (Antiglobulin) in Brucellosis

Wagner, Bernard M.; Kuhns, Dwight M.

doi:10.1093/ajcp/23.2_ts.185

Cited by 8 publications

(2 citation statements)

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“…Elberg (1958) 630 has outlined procedures that might be followed in testing for incomplete blocking type antibodies, but says that when the normal tube test is carried out properly many difficulties formerly reported are obviated; however, he still leaves room for a technique to allow for incomplete or blocking antibodies. The papers of Burki and Fey (1953), Hall and Manion (1953), Wagner and Kuhns (1953) and Cruickshank (1956) add support to the view that the blocking antibody test should be in routine use on serum negative to the tube test, or alternatively that an appropriate technique to allow for blocking antibodies should be in use with the tube test. Zinneman, Glenchur and Hall (1959) say that blocking antibodies appear later than the agglutinating antibodies; they appear first on the y globulins, but shift to the globulins and persist after agglutinating antibodies subside.…”

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confidence: 95%

Brucellosis in Children

Bothwell¹

1962

Archives of Disease in Childhood

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(1931) described the first case in an infant aged 20 months. Since then only three series of childhood brucellosis have been published, forming part of a series of cases of all ages (Beattie, Smith and Tulloch, 1935; Smith, 1951; Dalrymple-Champneys, 1960). A series of eight mild cases in childhood has been described by Paterson and Hardwick (1938 Dalrymple-Champneys has referred to childhood cases in his various intermediate papers (1950, 1952 When contact cases were excluded, however, the proportion of childhood cases increased, and in 74 proven cases with no animal contact nearly 10% were children under 10 years.Hagebusch and Frei (1941) had previously concluded that the disease was common but self-limited in childhood and that spontaneous recovery masked the real incidence. Of 182 cases of childhood brucelosis diagnosed by them, six were classified as acute and 176 as chronic; 95 % were under 6 years of age and 65% were female, corresponding with their experience of adult cases in St. Louis, where at that time 78 % of over 1,000 cases had been female.

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confidence: 95%

Brucellosis in Children

Bothwell¹

1962

Archives of Disease in Childhood

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“…The indirect Coombs test was performed as described by Wagner and Kuhns [12] with commercial rabbit immunoglobulin against guinea pig immunoglobulins (Dakopatts, Glostrup, Den mark) as second antibody. Reference Sera Reference sera against B.fragilis IPL E323 were prepared in rabbits as described by Meisel-Mikolajczyk and Puczyhska [8].…”

Section: Coombs Testmentioning

confidence: 99%

Immune Response to Endotoxin Isolated from <i>Bacteroides fragilis</i> in the Pregnant Guinea Pig

Beckmann

Meisel-Mikołajczyk²,

Leszczyński³

et al. 1990

Int Arch Allergy Immunol

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The humoral immune response to endotoxin isolated from Bacteroides fragilis was analyzed in the pregnant guinea pig by means of passive hemagglutination, passive hemolysis, a modified Coombs test, and by crossed immunoelectrophoresis. Pregnant animals were immunized with endotoxin on day 30 of gestation, and antibodies were determined on day 61 in maternal and fetal sera, and in amniotic fluid. The IgG and IgM responses in maternal sera were of the same magnitude as in sera of nonpregnant animals. Fetal sera contained IgG and sometimes IgM, and a higher percentage of incomplete antibodies against endotoxin than maternal sera. Low-titer anti-endotoxin antibodies, partially sensitive to dithiothreitol, were found in amniotic fluid. A statistically significant reduction in the growth of fetuses from endotoxin-immunized females was observed.

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The transfer of serum proteins from mother to young in the guinea pig. I. Prenatal rates and routes

Leissring

Anderson

1961

Am. J. Anat.

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Coombs Type of Antibodies (Antiglobulin) in Brucellosis

Cited by 8 publications

References 0 publications

Brucellosis in Children

Brucellosis in Children

Immune Response to Endotoxin Isolated from <i>Bacteroides fragilis</i> in the Pregnant Guinea Pig

The transfer of serum proteins from mother to young in the guinea pig. I. Prenatal rates and routes

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