Introduction: The quick spread of SARS-CoV-2 led to the development of vaccines that are capable of reducing infection and the number of more severe COVID-19 cases. Aim: To assess COVID-19 prevalence among health care workers (HCWs) after vaccination against SARS-CoV-2. Methods: Cross-sectional study on the prevalence of COVID-19 diagnosis among 7.523 HCWs vaccinated against SARS-CoV-2 with Coronavac and ChAdOx1 nCoV-19 in a university hospital, in southern Brazil, between January 18, 2021 and March 18, 2021.The variables evaluated were: sex, age, work area, role, source of infection, previous diagnosis of COVID-19, date of vaccine administration, type of vaccine, and need for hospitalization. The statistical analysis used Poisson regression and Fisher's Exact Test with the SPSS software version 25 and level of significance set at 5%. Results: 813 vaccinated HCWs showed symptoms suggestive of COVID-19, and 35.4% (288) who underwent RT-PCR for SARS-CoV-2 had a detectable result. There was a reduction of 62% in new cases of COVID-19 among HCWs in the institution after seven weeks of the start of the vaccine rollout. Conclusion: Our data suggest that the vaccines used by the institution reduced the number of COVID-19 cases among health care workers, showing the effectiveness of the vaccines.
Introduction:
Cardiac involvement in COVID-19 can range from mild damage to severe myocarditis. The precise mechanism by which COVID-19 causes myocardial injury is still unknown. Myocarditis following administration of COVID-19 vaccines, especially those based on mRNA, has also been described. However, no reports of heart failure following reinfection with COVID-19 in patients immunized with an inactivated vaccine have been identified.
Case description
: Male, 47-year-old, of African descent, construction worker, with type II diabetes, with a history of infection by SARS-CoV-2 in December 2020 and May 2021, confirmed by RT-PCR. Received two doses of an inactivated vaccine against COVID-19. Between the two COVID-19 episodes with positive RT-PCR he had two episodes of bacterial lung infection. After the second episode of SARS-CoV-2 infection, he was diagnosed with severe heart failure as a sequelae of myocarditis.
Conclusion:
It is essential to do a proper follow-up after infection by SARS-CoV-2, since even with proper immunization, there is a possibility that the patient was reinfected and had severe cardiac sequelae as a consequence, and the hypothesis of an etiology associated with the use of an inactivated vaccine against COVID-19 with a potential immune enhancement mechanism following re-infection with SARS-CoV-2 cannot be rejected.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.