Reduction in COVID-19 prevalence in healthcare workers in a university hospital in southern Brazil after the start of vaccination

Toniasso, Sheila de Castro Cardoso; Fernandes, Fernando Schmidt; Joveleviths, Dvora; Filho, Fábio Fernandes Dantas; Takahasi, Anderson Yudi; Baldin, Camila Pereira; Pereira, Robson Martins; Silva, Luciana Pereira da; Brum, Maria Carlota Borba

doi:10.1016/j.ijid.2021.07.025

Cited by 15 publications

(13 citation statements)

References 10 publications

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“…There is now consolidated evidence that the onset of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection in healthcare facilities is associated with an enhanced risk of morbidity and mortality, both in hospitalized patients as well as in healthcare workers. Therefore, regular SARS-CoV-2 diagnostic testing and coronavirus disease 2019 (COVID-19) vaccination are now regarded as major cornerstones for preventing and/or limiting the burden of SARS-CoV-2 inside and outside healthcare facilities [1] . A recent study published by Yoshimura et al [2] evidenced a fairly good response in terms of anti-SARS-CoV-2 IgG level after a complete cycle of Pfizer BNT162b2 mRNA-based COVID-19 vaccine.…”

Section: Introductionmentioning

confidence: 99%

Total anti-SARS-CoV-2 antibodies measured 6 months after Pfizer-BioNTech COVID-19 vaccination in healthcare workers

Salvagno¹,

Henry²,

Pighi³

et al. 2022

J Med Biochemistry

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Background: This study aimed at monitoring the kinetics of serum total anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies in a cohort of healthcare workers after voluntary vaccination with Pfizer-BioNTech coronavirus disease 2019 (COVID-19).Methods: The study population consisted of 787 healthcare workers (mean age 44±12 years; 66% females), who received two 30 μg doses of Pfizer-BioNTech COVID-19 vaccine, 3 weeks apart. Venous blood was drawn before the first vaccine dose, immediately before the second vaccine dose, and then at 1, 3 and 6 months after the second vaccine dose. Serological testing employed the total anti-SARS-CoV-2 antibodies measurement with Roche Elecsys Anti-SARS-CoV-2 S chemiluminescent immunoassay.Results: The median serum levels of total anti-SARS-CoV-2 antibodies reached the peak (1762 KU/L) 1 month after the second vaccine dose, but tended to progressively decline at the 3-month (1086 KU/L) and 6-month (802 KU/L) follow-up points. Overall, the values after 3- and 6-months were 37% and 57% lower than the corresponding concentrations measured at the peak. No healthcare worker had total anti-SARS-CoV-2 antibodies below the method-dependent cut-off. The decline compared to the peak was more accentuated in baseline seropositive persons than in those who were baseline seronegative (74% vs. 52%) cohort. The 6-month post-vaccination anti-SARS-CoV-2 antibodies in subjects aged <65 years remained over 2-fold higher than that measured in those aged ≥65 years (813 vs. 343 KU/L). Conclusions: Gradual decline of total anti-SARS-CoV-2 antibodies occurred 6 months after Pfizer-BioNTech COVID-19 vaccination, though values remained higher than the method-dependent cut-off, with no case of seronegativization.

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Section: Introductionmentioning

confidence: 99%

Total anti-SARS-CoV-2 antibodies measured 6 months after Pfizer-BioNTech COVID-19 vaccination in healthcare workers

Salvagno¹,

Henry²,

Pighi³

et al. 2022

J Med Biochemistry

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“…Recent studies highlighted that vaccination campaigns were critical in reducing COVID-19 incidence among Brazilian healthcare workers 12 , 13 , hospital admissions, and deaths among older adults 11 , 14 . Overall, vaccinations have proven their efficacy in preventing COVID-19 fatalities 15 .…”

Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 vaccination on case fatality rates in a city in Southern Brazil

Passarelli-Araujo¹,

Pott-Júnior²,

Susuki³

et al. 2022

American Journal of Infection Control

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“…Recent studies have highlighted that vaccination campaigns have been instrumental in reducing the incidence of SARS-CoV-2 among Brazilian health professionals, hospital admissions and deaths among the elderly. Overall, vaccines have proven their effectiveness in preventing fatalities from SARS-CoV-2 (Victora et al, 2021;Toniasso et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Clinical-epidemiological characteristics and surveillance in monitoring SARS-CoV-2 in the municipality of Teresopolis, RJ, Brazil

Palatnic

Costa²,

Machado³

et al. 2022

RSD

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The high transmissibility of SARS-CoV-2 can be attributed to the unique virological characteristics of SARS-CoV-2. Early diagnosis is crucial to controlling the spread of SARS-CoV-2. The most common cardiovascular problems in patients with SARS-CoV-2 is acute myocardial injury. However, SARS-CoV-2 can cause direct and indirect cardiovascular sequelae, including acute coronary syndromes, cardiomyopathy, acute cor pulmonale, arrhythmias, and cardiogenic shock. Thus, as the disease progresses, there is a need for new clinical evidence based on epidemiological data and laboratory findings, and it is prudent to identify risk factors for the development of systemic complications associated with disease severity and may predict worse clinical outcomes. and increased mortality. The objective of the research is to evaluate and describe the clinical and epidemiological profile of SARS-CoV-2 cases, in order to assess the sociodemographic, clinical and epidemiological characteristics of individuals, seeking to subsidize the panorama of the spread of the disease, protection of the population through vaccination. , as well as the prevalence of diagnoses resulting from the virus in the city of Teresópolis - RJ, to assist in the understanding of the disease and its effects, so that solutions can be sought.

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Reduction in COVID-19 prevalence in healthcare workers in a university hospital in southern Brazil after the start of vaccination

Cited by 15 publications

References 10 publications

Total anti-SARS-CoV-2 antibodies measured 6 months after Pfizer-BioNTech COVID-19 vaccination in healthcare workers

Total anti-SARS-CoV-2 antibodies measured 6 months after Pfizer-BioNTech COVID-19 vaccination in healthcare workers

The impact of COVID-19 vaccination on case fatality rates in a city in Southern Brazil

Clinical-epidemiological characteristics and surveillance in monitoring SARS-CoV-2 in the municipality of Teresopolis, RJ, Brazil

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