Objective: This study aimed to compare the first trimester complete blood count (CBC) indices of pregnancies complicated by early-onset preeclampsia (EOPE) or late-onset preeclampsia (LOPE). Material and Methods: A retrospective case-control study was conducted with 186 patients. Patients were classified into three subgroups: EOPE, LOPE, and control groups. First trimester CBC results were obtained for each patient. Hemoglobin, hematocrit, red blood cell distribution width, mean corpuscular volume, white blood cell (WBC) count, neutrophil, eosinophil, basophil, lymphocyte, monocyte, mean platelet volume, platelet distribution width, plateletcrit, and platelet count were compared. The neutrophil lymphocyte ratio was calculated by dividing the absolute lymphocyte count by the absolute neutrophil count. The platelet lymphocyte ratio was calculated by dividing the absolute lymphocyte count by the absolute platelet count. Results: The total number of cases was 21, 42, and 123, in the EOPE, LOPE, and control groups, respectively. There were statistically significant differences in the total WBC and neutrophil counts between the three groups (both p<0.05). WBC and neutrophil counts were found to be highest in the EOPE group, and the LOPE group had higher levels compared with controls. The optimal cut-off values to predict EOPE for WBC and neutrophil counts were 9.55×10 3 / μL (sensitivity 71.4% and specificity 70.7%) and 6.45×10 3 /μL (sensitivity 66.7% and specificity 74.8%), respectively. Conclusion: Increased first trimester WBC and neutrophil counts may be predictive for EOPE.

Background/aim: The HIV-infected population is aging, and the concomitant comorbidities increase the likelihood of polypharmacy. There is a scarcity of data for determining drug-related problems in people living with HIV/AIDS (PLWHA). Materials and methods: This cross-sectional study was carried out between September 1, 2015, and July 1, 2016. All patients underwent a face-to-face interview with a clinical pharmacist. The 'PCNE Classification V 7.0.' was used classify incident drug-related problems (DRPs). Results: The mean age of the patients was 40.4±13.06 years. The rate of polypharmacy was 66.1% in patients with comorbidities and 12.3% in those without comorbidities (p<0.001). DRPs were more prominent in older patients (46 vs. 37 years, p<0.001), with longer duration of antiretroviral therapy (ART) (45 vs. 27 months, p=0.014), and with lower education level (p=0.013). Receiving >3 ART drugs was associated with more DRPs in the logistic regression model (odds ratio: 8.299, 95% confidence interval: 1.924–35.803). Fifty-eight interventions were performed in 45 (24.9%) patients. Clinical pharmacist interventions were performed in 18.9% of patients without polypharmacy and in 38.9% of patients with polypharmacy (p<0.001). Conclusion: DRPs and polypharmacy are common among elderly PLWHA. More interventions are warranted to boost the quality of life in aging PLWHA. Keywords: human immunodeficiency virus, polypharmacy, drug-related problems

The 50-g GCT can be used to identify women at risk of delivering offspring with excessive delivery weight.

BackgroundJuvenile idiopathic arthritis (JIA) is a chronic inflammatory childhood disease with symptoms such as joint inflammation, pain and loss of quality of life.1 Types of disease and the presence of pain can impact the child psychosocially, as well as affecting functional activity.2 ObjectivesThe aim of this study is to examine the results of functional and psychosocial status according to the disease type and the presence of pain symptoms in children with JIA.MethodsThe study included 71 children diagnosed with JIA who applied to the Hacettepe University İhsan Doğramacı Children’s Hospital Rheumatology Department. Following the collection of demographic information, functional status was assessed with the Child Health Assessment Questionnaire (CHAQ) and psychosocial and functional status was assessed with the scale developed in Hacettepe University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation for functional and psychosocial status of children with rheumatism by Edibe Ünal.3 Children were divided into groups according to disease type as oligoarthritis or polyarthritis and the presence or absence of pain.ResultsTable 1 shows the mean age and numbers of children. There was no difference between the groups according to disease type (p>0,05). On the other hand, comparing scores for the CHAQ total, CHAQ general VAS assessment, functional and psychosocial status according to the presence or absence of pain revealed significant differences (p<0,05).Abstract AB1452HPR – Table 1Assessment values and comparison statisticsDisease TypePain Oligoarthritis(n=51)Polyarthritis(n=20) pPresent(n=21)Absent(n=50) p Age (years)10,88±3,8113,50±3,92001611,71±3,7711,58±4,120885CHAQ Total0,28±0,290,46±0,4101270,51±0,40,26±0,270012CHAQ (General VAS)2,49±2,433,93±300684,46±2,862,24±2,30002Function (range 0–30)4,72±4,855,05±6,3207667,85±6,63,54±4,020004Psychosocial (range 0–30)23±5,6714,5±5,82036316±5,7412,34±5,40012Function; Psychosocial; Functional and Psychosocial subscales of Ünal’s scale.3 ConclusionsWe conclude that pain has a greater effect on functional, psychosocial and overall disease assessment in children with JIA when compared to the disease type. Thus, it must be taken into consideration that child’s ability to cope with pain should be improved.References[1] Angelo Ravelli, Alberto Martini. Juvenile idiopathic arthritis.The Lancet2007, 369(9563); 767–778.[2] Laura E Schanberga, John C Lefebvreb, et al. Pain coping and the pain experience in children with juvenile chronic arthritis. Pain1997, 73(2); 181–189.[3] Kısacık Pınar,Ünal Edibe, et al. Juvenil İdiyopatik Artritli Hastalarda Çok Yönlü Bir Değerlendirme Sistemi Oluşturulması Delphi Çalışması. 2016, Annals Of Paediatric Rheumatology Disclosure of InterestNone declared

BackgroundJuvenile Idiopathic Arthritis (JIA) is the most frequent chronic rheumatic disease during childhood. It can result in disabilities, loss of quality of life and mood changes.1 Furthermore, literature reviewing the effects of arthritis on children and family is inonsistent, with studies showing significant difference or not, compared to healthy children.2 ObjectivesThe purpose of this study is to present results regarding the functional status, psychosocial status and disease activity of children with JIA and their effects on the child’s family. The second aim is to present the correlations between these parameters.MethodsThe study included children diagnosed with JIA who applied to Hacettepe University İhsan Doğramacı Children’s Hospital Rheumatology Department. After demographic data was collected, all children were assessed with Child Health Assessment Questionnaire (CHAQ) for daily living activities, with the Juvenile Arthritis Disease Activity Score (JADAS) for disease activity and with a newly developed scale from Hacettepe University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation for children with rheumatism by Edibe Ünal(3 for functional and psychosocial status. Cut-off point was accepted as ≤2.7 for disease activity.4 The Family Impact Scale (FIS) was used to assess perspective of parents.ResultsA hundred and ninety-six children were included in the study. The mean age of children was 12,44±3,97 and female/male ratio was 55,6/44,4. Although the mean JADAS score was 3,33±4,21, it only detected active disease in 81 children. There was a moderate correlation between CHAQ (Pain) and functional scores of Ünal’s scale and JADAS score. CHAQ total score was well correlated with function and psychosocial scores. The correlation between FIS and other scales was very low.Abstract AB1447HPR – Table 1DescriptivesMean±SD JADAS3,33±4,21CHAQ (Total)0,32±0,38CHAQ (Pain)2,31±3,01CHAQ (General VAS)3,52±2,99Function (range: 0–30)4,09±5,85Psychosocial (range: 0–30)13,25±5,76FIS43,6±10.12Function; Psychosocial; Functional and Psychosocial subscales of Ünal’s scale.3 Abstract AB1447HPR – Table 2CorrelationsConclusionsOur results show that pain and function alter disease activity in children with JIA. It is seen that psychosocial states of children and their functional states expressed by their own knowledges also affect their daily life. These changes did not affect the wievpoint of the family.References[1] Spiegel L, Kristensen KD, et al. Juvenile idiopathic arthritis characteristics: Etiology and pathophysiology. Seminars in Orhodontics2015, 21(2); 77–83[2] Susan T. Reisine. Arthritis and the Family. Arthritis Rheum1995, 8(4);265–271.[3]. Kısacık Pınar,Ünal Edibe, et al. Juvenil İdiyopatik Artritli Hastalarda Çok Yönlü Bir Değerlendirme SistemiOluşturulması Delphi Çalışması. 2016, Annals Of Paediatric Rheumatology.[4] Bulasovic Calasan M, De Vries LD, et al. Interpretation of the Juvenile Arthritis Disease Activity Socre: responsiveness, clinically important differences and levels of disease...