Use of the 50‐g glucose challenge test to predict excess delivery weight

Beksaç, Mehmet Sinan; Haklı, Duygu Aydın; Özyüncü, Özgür

doi:10.1002/ijgo.12504

Cited by 9 publications

(7 citation statements)

References 24 publications

(44 reference statements)

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“…4,7,29 Moreover, these screening tests not only detect high-risk groups for GDM but they may also provide useful information about the growth potential of the fetuses. 30,31 Excessive delivery weight was found to be associated with increased 50-g GCT values, and higher 2nd-hour 75-g GTT values were observed in pregnant women who delivered large-for gestational-age newborns. 30,31 There are some studies in the literature investigating the effect of low screening test results on obstetric outcomes; these have some limitations related to the study design, standardization of protocols, study population, and the inclusion of other confounding factors.…”

Section: Discussionmentioning

confidence: 99%

“…30,31 Excessive delivery weight was found to be associated with increased 50-g GCT values, and higher 2nd-hour 75-g GTT values were observed in pregnant women who delivered large-for gestational-age newborns. 30,31 There are some studies in the literature investigating the effect of low screening test results on obstetric outcomes; these have some limitations related to the study design, standardization of protocols, study population, and the inclusion of other confounding factors. [8][9][10][11][12][13][14][15][16] Moreover, optimum definition and the appropriate cutoff value for low 50-g GCT results have not yet been determined.…”

Section: Discussionmentioning

confidence: 99%

“…Screening may be performed either by a one‐step approach with the 75‐g oral GTT or a two‐step approach with the 50‐g GCT 4,7,29 . Moreover, these screening tests not only detect high‐risk groups for GDM but they may also provide useful information about the growth potential of the fetuses 30,31 . Excessive delivery weight was found to be associated with increased 50‐g GCT values, and higher 2nd‐hour 75‐g GTT values were observed in pregnant women who delivered large‐for gestational‐age newborns 30,31 …”

Section: Discussionmentioning

confidence: 99%

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Use of the 50‐g glucose challenge test to predict small‐for‐gestational‐age neonates

Eyupoglu

Fadıloğlu

Zengin

et al. 2020

Journal of Diabetes

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Background: To determine a cutoff value for the 50-g glucose challenge test (50-g GCT) for the prediction of small-for-gestational-age (SGA) neonates. Methods: This retrospective cohort study was conducted among pregnant women who were screened with the 50-g GCT at Hacettepe University Hospital between 1 January 2016 and 31 March 2019. Patients with 50-g GCT values <74 mg/dL (<10th percentile) served as the study group (n = 244), while patients with 50-g GCT values between 74 to 139 mg/dL served as the control group (n = 3104). Groups were compared in terms of demographic features, clinical characteristics, and obstetric outcomes. Logistic regression analysis was used to determine independent predictors of SGA. Receiver operating characteristic curves were used to assess the performance of 50-g GCT values in predicting SGA. Results: Lower birthweight, birthweight percentile, and 5th-minute Apgar values, together with higher rates of SGA, were observed in the study group (P < .001 for all). A 50-g GCT value below the 10th percentile (odds ratio: 3.29, 95% CI: 2.31-4.69, P < .001) was a significant independent factor for SGA. A cutoff value of 89.5 mg/dL (84.9% sensitivity, 85.6% specificity) was determined for SGA. Conclusions: Low 50-g GCT values (<89.5 mg/dL) may be an early indicator for SGA. K E Y W O R D S 50-g glucose challenge test, cutoff value, gestational diabetes mellitus, pregnancy, screening, small for gestational age Highlights Low 50-g glucose challenge test (50-g GCT) values may be an early indicator for SGA neonates, and physicians should be cautious especially with regard to values less than 89.5 mg/dL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Use of the 50‐g glucose challenge test to predict small‐for‐gestational‐age neonates

Eyupoglu

Fadıloğlu

Zengin

et al. 2020

Journal of Diabetes

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“…Our study found that prepregnancy overweight/obesity increased the risk of birth LGA and was partially mediated by FPG and TG levels from 24 to 28 weeks of gestation. In addition, studies have also found that 50 g GCT can be used to identify women at risk of delivering overweight infants or small for gestational age neonates [ 45 , 46 ]. Excess birth weight has been found to be associated with increased 50 g GCT values in pregnant women delivering large for gestational age babies [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, studies have also found that 50 g GCT can be used to identify women at risk of delivering overweight infants or small for gestational age neonates [ 45 , 46 ]. Excess birth weight has been found to be associated with increased 50 g GCT values in pregnant women delivering large for gestational age babies [ 46 ]. In Finland and Poland, 50 g GCT is preferred for universal screening of GDM [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Mediation effect of maternal triglyceride and fasting glucose level on the relationship between maternal overweight/ obesity and fetal growth: a prospective cohort study

Wan

Chen

et al. 2023

BMC Pregnancy Childbirth

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Background Previous studies have suggested that maternal overweight/obesity is asscociated with macrosomia. The present study aimed to investigate the mediation effects of fasting plasma glucose (FPG) and maternal triglyceride (mTG) in the relationship between maternal overweight/obesity and large for gestational age (LGA) among non-diabetes pregnant women. Methods This prospective cohort study was conducted in Shenzhen from 2017 to 2021. A total of 19,104 singleton term non-diabetic pregnancies were enrolled form a birth cohort study. FPG and mTG were measured at 24–28 weeks. We analyzed the association of maternal prepregancy overweight/obesity with LGA and mediation effects of FPG and mTG. Multivariable logistic regression analysis and serial multiple mediation analysis were performed. The odds ratio (OR) and 95% confidence intervals (CIs) were calculated. Results Mothers who were overweight or obese had higher odds of giving birth to LGA after adjusting potential confounders (OR:1.88, 95%CI: 1.60–2.21; OR:2.72, 95%CI: 1.93–3.84, respectively). The serial multiple mediation analysis found prepregnancy overweight can not only have a direct positive effect on LGA (effect = 0.043, 95% CI: 0.028–0.058), but also have an indirect effect on the LGA through two paths: the independent mediating role of FPG (effect = 0.004, 95% CI: 0.002–0.005); the independent mediating role of mTG (effect = 0.003,95% CI: 0.002–0.005). The chain mediating role of FPG and mTG has no indirect effect. The estimated proportions mediated by FPG and mTG were 7.8% and 5.9%. Besides, the prepregnancy obesity also has a direct effect on LGA (effect = 0.076; 95%CI: 0.037–0.118) and an indirect effect on LGA through three paths: the independent mediating role of FPG (effect = 0.006; 95%CI: 0.004–0.009); the independent mediating role of mTG (effect = 0.006; 95%CI: 0.003–0.008), and the chain mediating role of FPG and mTG (effect = 0.001; 95%CI: 0.000-0.001). The estimated proportions were 6.7%, 6.7%, and 1.1%, respectively. Conclusion This study found that in nondiabetic women, maternal overweight/obesity was associated with the occurence of LGA, and this positive association was partly mediated by FPG and mTG, suggesting that FPG and mTG in overweight/obese nondiabetic mothers deserve the attention of clinicians.

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Management of Gestational Diabetes Mellitus

Oskovi-Kaplan

Özgü-Erdinç

2020

Advances in Experimental Medicine and Biology

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Use of the 50‐g glucose challenge test to predict excess delivery weight

Abstract: The 50-g GCT can be used to identify women at risk of delivering offspring with excessive delivery weight.

Cited by 9 publications

References 24 publications

Use of the 50‐g glucose challenge test to predict small‐for‐gestational‐age neonates

Use of the 50‐g glucose challenge test to predict small‐for‐gestational‐age neonates

Mediation effect of maternal triglyceride and fasting glucose level on the relationship between maternal overweight/ obesity and fetal growth: a prospective cohort study

Management of Gestational Diabetes Mellitus

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