From the methanolic extract of the roots of Clerodendrum philipinum, a new rearranged abietane diterpene (1) and eight known compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D-and 2D-NMR, as 17(15→16),18(4→3)-bisabeo-11,12,14,16-tetrahydroxy-3,5,8,11,13,15-abietahexaen-7-one (1), binankadsurin A, clerodenoside A, martynoside, acteoside, isoacteoside, astragalin, β-sitosterol, and daucosterol. Binankadsurin A was found for the first time from a Clerodendrum species.
The products EB containing of eleutherine and isoeleutherine have been extracted from the rhizome of Eleutherine bulbosa and showed the antibacterial effect on experimental animals. Based on the results of diameter of sterile ring using the agar diffusion method, EB products have a significant antibacterial effect against Bacillus subtilis, Staphylococcus aureus, Shigella flexneri DT 112, Proteus mirabilis BV 108 and Bacillus pumilus at concentrations of 50 µg/ml and 100 µg/ml. The EB products exhibited also their antibacterial activity in vivo on the experimental thermal burn in the rabbit skin, reducing the density of bacterial/cm 2 at 7 days after treatment by EB ointment, these antibacterial effect of EB is equivalent to sulfadiazine-1% silver.
The products EB containing of eleutherine and isoeleutherine have been extracted from the rhizome of Eleutherine bulbosa and showed the antibacterial effect on experimental animals. Based on the results of diameter of sterile ring using the agar diffusion method, EB products have a significant antibacterial effect against Bacillus subtilis, Staphylococcus aureus, Shigella flexneri DT 112, Proteus mirabilis BV 108 and Bacillus pumilus at concentrations of 50 µg/ml and 100 µg/ml. The EB products exhibited also their antibacterial activity in vivo on the experimental thermal burn in the rabbit skin, reducing the density of bacterial/cm 2 at 7 days after treatment by EB ointment, these antibacterial effect of EB is equivalent to sulfadiazine-1% silver.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.