A New Rearranged Abietane Diterpene and other Constituents from <i>Clerodendrum Philipinum</i>

Oanh, Ha Van; Sinh, Pham Xuan; An, Nguyen Thai; Hung, Ta Manh; Hương, Trần Thị Lan; Que, Do Thi Nguyet; Thảo, Nguyễn Phương; Cường, Nguyễn Xuân; Dat, Nguyen Tien; Minh, Châu Văn; Kiệm, Phan Văn

doi:10.1177/1934578x0900400304

Natural Product Communications

2009

DOI: 10.1177/1934578x0900400304

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A New Rearranged Abietane Diterpene and other Constituents from Clerodendrum Philipinum

Ha Van Oanh

Pham Xuan Sinh

Nguyen Thai An

et al.

Abstract: From the methanolic extract of the roots of Clerodendrum philipinum, a new rearranged abietane diterpene (1) and eight known compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D-and 2D-NMR, as 17(15→16),18(4→3)-bisabeo-11,12,14,16-tetrahydroxy-3,5,8,11,13,15-abietahexaen-7-one (1), binankadsurin A, clerodenoside A, martynoside, acteoside, isoacteoside, astragalin, β-sitosterol, and daucosterol. Binankadsurin A was found for … Show more

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Cited by 3 publications

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“…Clerodendrum (family Verbenaceae) is a genus of about 400 species, which has been widely used in Vietnamese traditional medicine for treatment of cough, fever, inflammation, hepatitis and pulmonary tuberculosis, and as a phlogistic [1,2]. Plants of the genus have proved to be a rich source of abietane diterpenes, as well as iridoids, triterpenes, phenylethanoid glycosides and saponins, which have been found to possess many beneficial pharmacological effects [3][4][5][6][7][8][9][10].…”

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Bioactive Diterpenes from Clerodendrum kaichianum

Shen

Wang

et al. 2011

Natural Product Communications

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Bioassay-guided isolation studies of the extract of Clerodendrum kaichianum Hsu., a new rearranged abietane diterpene and five known diterpene compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D-and 2D-NMR spectroscopy, as (16R)-12,16-epoxy-11,14,17-trihydroxy-17(15→16)-abeo-8,11,13-abietatrien-7-one (1), villosin A (2), salvinolone (3), 14-deoxyloleon U (4), 5,6-dehydrosugiol (5), and coleon U (6). Compounds 1, 2, 3, and 5 are reported for the first time for this genus. Compounds 1, 2, and 6 demonstrated potent cytotoxic activities against the HL-60 tumor cell line.

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mentioning

confidence: 99%

Bioactive Diterpenes from Clerodendrum kaichianum

Shen

Wang

et al. 2011

Natural Product Communications

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Traditional uses and pharmacological properties of Clerodendrum phytochemicals

Wang

Luan²,

et al. 2018

Journal of Traditional and Complementary Medicine

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Clerodendrum is a genus of ca. 500 species in the family Lamiaceae and widely distributed throughout the whole world. Up to now, many species of this genus have been described in various indigenous systems of medicine and are used in preparation of folklore medicines for the treatment of various life-threatening diseases, and more than eleven species of the Clerodendrum genus have been very well studied for their chemical constituents and biological activities, and 283 compounds, including monoterpene and its derivatives, sesquiterpene, diterpenoids, triterpenoids, flavonoid and flavonoid glycosides, phenylethanoid glycosides, steroids and steroid glycosides, cyclohexylethanoids, anthraquinones, cyanogenic glycosides, and others have been isolated and identified. Pharmacological studies have shown that these compounds and extracts from the Clerodendrum genus have extensive activities, such as anti-inflammatory and anti-nociceptive, anti-oxidant, anti-hypertensive, anticancer, antimicrobial, anti-diarrheal, hepatoprotective, hypoglycemic and hypolipidemic, memory enhancing and neuroprotective, and other activities. In this review, we attempt to highlight over phytochemical progress and list the phytoconstituents isolated from the genus Clerodendrum reported so far. The biological activities of this genus are also covered.

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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Riaz

Rasul

Hussain

et al. 2018

Advances in Pharmacological Sciences

163

113

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Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.

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A New Rearranged Abietane Diterpene and other Constituents from Clerodendrum Philipinum

Cited by 3 publications

References 19 publications

Bioactive Diterpenes from Clerodendrum kaichianum

Bioactive Diterpenes from Clerodendrum kaichianum

Traditional uses and pharmacological properties of Clerodendrum phytochemicals

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

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