Traditional uses and pharmacological properties of Clerodendrum phytochemicals

Wang, Jinhui; Luan, Fei; He, Xiangdong; Wang, Yong; Li, Maoxing

doi:10.1016/j.jtcme.2017.04.001

Cited by 69 publications

(50 citation statements)

References 86 publications

(90 reference statements)

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“…Moreover, its phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, saponosides, tannins, and triterpenes [4]. In a murine model of Schistosoma mansoni infection, the methanolic fraction from CuAE exhibited schistosomicidal, hepatoprotective, and antioxidant properties [6,7].…”

Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic oral toxicity studies of the leaves aqueous extract of Clerodendrum umbellatum Poir. on mice

Jatsa¹,

Fassi²,

Kenfack³

et al. 2018

A J Physiol Biochem Pharmacol

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Aim: The schistosomicidal activity of Clerodendrum umbellatum leaves aqueous extract (CuAE) has been previously demonstrated. The present study was performed to establish the acute and sub-chronic oral toxicity profile of CuAE in mice. Methods: For acute oral toxicity study, CuAE was administered per os to female mice at a single dose of 2,000 mg/kg. Animals were observed for 14 days in order to identify the signs of toxicity or death. In the repeated dose 28-day oral toxicity study, the extract was administered daily and per os to female and male mice at doses of 200, 400, and 800 mg/kg for 28 consecutive days. A satellite group was also set up. Body weight was measured weekly. Hematological, biochemical, and histopathological parameters were analyzed. Results: CuAE at 2,000 mg/kg produced no sign of toxicity or mortality. In the sub-chronic toxicity study, no mortality, no significant change in the body weight, the relative organ weights, and the hematological parameters were recorded in all treated mice. CuAE at 400 mg/kg significantly increased transaminases activities in male mice. Except for creatinine and high-density lipoprotein-cholesterol in which concentrations are increased after administration of CuAE at 800 mg/kg, the levels of others biochemical markers didn't change. Histopathological abnormalities found in the kidneys were reversible. Conclusion: These results indicated that the LD 50 of CuAE is greater than 2,000 mg/kg and CuAE, therefore, belongs to the category five of relatively non-toxic substances. From the sub-chronic toxicity study, the no-observed-adverse-effect level of CuAE for both male and female mice was considered to be 200 mg/kg/day.

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Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic oral toxicity studies of the leaves aqueous extract of Clerodendrum umbellatum Poir. on mice

Jatsa¹,

Fassi²,

Kenfack³

et al. 2018

A J Physiol Biochem Pharmacol

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“…stephensi which may be due to the presence of active biological compounds including terpenoids, flavonoid, alkaloids and phenolics etc. [28][29] The above mentioned compounds may jointly or independently contribute to impact on larvicidal and pupicidal activity against An. stephensi and a similar report was given by Subarani et al in which aqueous and solvent leaf extracts of Catharanthus roseus is able to impact on An.…”

Section: Discussionmentioning

confidence: 99%

Larvicidal and Pupicidal activity of Clerodendrum philippinum Schauer Leaf Extracts against Anopheles stephensi and Aedes aegypti

Dhal¹,

Rout²,

Dash³

et al. 2018

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Mosquitoes are serious human disease causing insects which transmit many dreadful diseases and therefore they are considered as 'public enemy number one'. 1-2 They are contributing as major public health issues by transmitting many life threatening diseases like malaria, dengue, chikungunya, filariasis, encephalitis, yellow fever and West Nile fever in almost all developed and developing countries of world. 3-4 Anopheles stephensi is a primary vector for malaria whereas, Aedes aegypti is responsible for causing dengue as well as chikungunya mainly in Asian countries including India. 5-6 Malaria caused by An. stephensi has become a major contribution in India and are particularly transmitting in the urban and industrial area. 7-8 In other hands, more than 70,000 and 18,000 cases of dengue and chikungunya, respectively are reported in India caused by Ae. aegypti. 9 Many control majors (environmental sanitation, epide miological, surveillance, laboratory and research support and education) are available to check against the vectors, those are responsible for spreading the different life threatening disease. 10 Moreover, synthetic insecticides are applied to control the agents but have

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“…C. inerme and C. viscosum, perennial shrubs of the family Lamiaceae, are therapeutically important plant species possessing immense traditional uses and pharmacological properties (Chethana et al 2013, Nayeem and Mehta 2015, Nandi and Lyndem 2016, Wang et al 2018. The present investigation describes the cytotoxic effect of aqueous and methanolic leaf extracts of C. inerme and C. viscosum using the Allium test.…”

mentioning

confidence: 93%

Assessment of Cytotoxic Effects of Aqueous and Methanolic Leaf Extracts of Clerodendrum inerme (L.) Gaertn. and C. viscosum Vent. Using Allium Test

Roy

2019

CYTOLOGIA

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Aqueous and methanolic leaf extracts of two medicinal plants, Clerodendrum inerme (L.) Gaertn. and C. viscosum Vent. (Family: Lamiaceae) were evaluated on root tip mitotic cells of Allium cepa L. for assessment of cytotoxicity relevant to their potential applicability for therapeutic uses. Results revealed mitodepressive as well as cytotoxic effects in mitotic cells of Allium test system following treatments with the extracts; however, the manifestation of effects was differential in relation to extract types and concentrations. Aberration types encountered in dividing and resting cells of A. cepa highlight cytotoxic potentiality of the extracts. The present study is therefore significant for biomonitoring of the cytotoxic effects with studied leaf extracts.

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Traditional uses and pharmacological properties of Clerodendrum phytochemicals

Cited by 69 publications

References 86 publications

Acute and sub-chronic oral toxicity studies of the leaves aqueous extract of Clerodendrum umbellatum Poir. on mice

Acute and sub-chronic oral toxicity studies of the leaves aqueous extract of Clerodendrum umbellatum Poir. on mice

Larvicidal and Pupicidal activity of Clerodendrum philippinum Schauer Leaf Extracts against Anopheles stephensi and Aedes aegypti

Assessment of Cytotoxic Effects of Aqueous and Methanolic Leaf Extracts of <i>Clerodendrum inerme</i> (L.) Gaertn. and <i>C. viscosum</i> Vent. Using <i>Allium</i> Test

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