Toxicity, analgesic and anti-inflammatory activities of tectorigenin

Ha, Le Minh; Que, Do Thi Nguyet; Huyen, Do Thi; Long, Pham Quoc; Dat, Nguyen Tien

doi:10.3109/08923973.2013.770521

Cited by 21 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 25 ] As for tectorigenin, previous research found that the median lethal dose of tectorigenin on mice was 1.78 g/kg. [ 12 ] The research also demonstrated that tectorigenin showed no toxicity to mice at a high dose of 300 mg/kg. However, the toxicity of tectorigenin has not been studied in guinea pigs yet.…”

Section: Discussionmentioning

confidence: 98%

“…Belamcanda chinensis is a traditional Chinese medicine, which has been used to treat cough and pharyngitis in many Eastern countries. [ 12 ] Tectorigenin is a main component of B. chinensis , and it is a methoxylated isoflavone with various biological activities, including antioxidation, hepatoprotection and anti‐inflammation. [ 13,14 ] The anti‐inflammatory effect of tectorigenin has been investigated and reported in several researches.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs

Wang

Jing

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives The aim of this study was to evaluate the effect of tectorigenin on treating allergic asthma model of guinea pigs and investigate the underlying mechanisms. Methods Allergic asthma model of guinea pigs was established by sensitizing with ovalbumin (OVA). Then OVA-sensitized guinea pigs were injected with 10 mg/kg tectorigenin, 25 mg/kg tectorigenin or dexamethasone to investigate the effect of tectorigenin. Key findings High dose of tectorigenin effectively decreased the number of coughs, the number of inflammatory cells and the levels of pro-inflammatory factors. Moreover, tectorigenin could inhibit pulmonary fibrosis in guinea pigs sensitized with OVA. In addition, the functions of tectorigenin were realized through downregulating profibrotic factors of transforming growth factor (TGF)-b1, phosphorylated (p)-Smad2/3 and Smad4, upregulating fibrosis-inhibitor of Smad7 and decreasing pro-inflammatory factors of vascular endothelial growth factor A (VEGFA), tumour necrosis factor-a (TNF-a), Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), p-inhibitor of nuclear factor-kappa B (NF-jB) kinase b (p-IKKb) and NF-jB. Conclusions Tectorigenin could inhibit pulmonary fibrosis and airway inflammation through TGF-b1/Smad signalling pathway and TLR4/NF-jB signalling pathway. Therefore, tectorigenin might be a promising medicine to treat allergic asthma.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs

Wang

Jing

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…In spite of being a more appropriate assay for opioids, this acetic acid-induced writhing test is widely used as a model of induction of inflammatory origin pain, as the acetic acid solution induces the synthesis of arachidonic acid metabolites and other inflammation mediators (Ha et al, 2013). Thus, the antinociceptive effects of non-steroidal anti-inflammatories and peripheral analgesics may also be observed from this model.…”

Section: Discussionmentioning

confidence: 99%

Pereskia aculeata: A plant food with antinociceptive activity

Pinto

Duque

Pacheco

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…( Furusawa et al, 2009 ; Zhu et al, 2019 ). In addition, tectorigenin which is an effective component derived from Belamcanda chinensis, has attracted considerable interest because of its anti-inflammatory activity ( Ha le et al, 2013 ; Pan et al, 2008 ). However, their targets for anti-inflammatory activity were not clear.…”

Section: Discussionmentioning

confidence: 99%

Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays

Hou

Shen

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance Traditional Chinese medicine (TCM) has a long history in the prevention and treatment of pandemics. The TCM formula Lung Cleansing and Detoxifying Decoction (LCDD), also known as Qing Fei Pai Du Decoction, has been demonstrated effective against Coronavirus Disease 2019 (COVID-19). Aim of the study This work aimed to elucidate the active ingredients, targets and pathway mechanism of LCDD related to suppression of inflammatory, immunity regulation and relaxation of airway smooth muscle for the treatment of COVID-19. Materials and methods Mining chemical ingredients reported in LCDD, 144 compounds covering all herbs were selected and screened against inflammatory-, immunity- and respiratory-related GPCRs including GPR35, H1, CB2, B2, M3 and β2-adrenoceptor receptor using a label-free integrative pharmacology method. Further, all active compounds were detected using liquid chromatography-tandem mass spectrometry, and an herb-compound-target network based on potency and content of compounds was constructed to elucidate the multi-target and synergistic effect. Results Thirteen compounds were identified as GPR35 agonists, including licochalcone B, isoliquiritigenin, etc. Licochalcone B, isoliquiritigenin and alisol A exhibited bradykinin receptor B2 antagonism activities. Atractyline and shogaol showed as a cannabinoid receptor CB2 agonist and a histamine receptor H1 antagonist, respectively. Tectorigenin and aristofone acted as muscarinic receptor M3 antagonists, while synephrine, ephedrine and pseudoephedrine were β2-adrenoceptor agonists. Pathway deconvolution assays suggested activation of GPR35 triggered PI3K, MEK, JNK pathways and EGFR transactivation, and the activation of β2-adrenoceptor mediated MEK and Ca 2+ . The herb-compound-target network analysis found that some compounds such as licochalcone B acted on multiple targets, and multiple components interacted with the same target such as GPR35, reflecting the synergistic mechanism of Chinese medicine. At the same time, some low-abundance compounds displayed high target activity, meaning its important role in LCDD for anti-COVID-19. Conclusions This study elucidates the active ingredients, targets and pathways of LCDD. This is useful for elucidating multitarget synergistic action for its clinical therapeutic efficacy.

show abstract

Toxicity, analgesic and anti-inflammatory activities of tectorigenin

Abstract: We demonstrated that tectorigenin is a safe and promising analgesic and anti-inflammatory agent.

Cited by 21 publications

References 13 publications

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs

Pereskia aculeata: A plant food with antinociceptive activity

Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays

Contact Info

Product

Resources

About