Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.
Supplementary Figure: 1 Peptide deformylase Sequence comparison. Peptide deformylase sequence analysed for conserved and least conserved regions with four Gram negative bacteria.Red colour box indicates conserved residues through the group. CD loop region between residue 68-72, shows least conserved residues for H.pylori. Major three motif regions indicated with a star. Sequence alignment was done using ESpript3 software ( https://espript.ibcp.fr/ESPript/ESPript/ ). Supplementary Figure: 2 Schematic 2-dimensional representation of binding mode of ZINC ligands with HpPDF S1 active site residues: (a) Actionin, (b) ZINC00225109, (c) ZINC44896875. Cobalt metal is represented in green colour. Hydrogen bonds formed indicated in dotted lines. Major binding site residues in contact with ligand represented as ball and sticks, other residues within the active site are labeled. LIGPLOT software was employed to visualize the interactions.
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