Efflux pumps potential drug targets to circumvent drug Resistance – Multi drug efflux pumps of Helicobacter pylori

Raj, Divya S.; Kesavan, Dinesh Kumar; Muthusamy, Natarajan; Umamaheswari, S.

doi:10.1016/j.matpr.2020.11.955

Cited by 12 publications

(16 citation statements)

References 50 publications

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“…As was mentioned previously, the transport of medicines across the brain capillary endothelial cells is exceedingly challenging because of the strict properties of the BBB provided by the tight junction [ 49 ]. Figure 5 illustrates how the existence of efflux pumps further complicates the already challenging task of medication distribution [ 53 ]. Near the cell surface, or luminal side, of BBB endothelial cells.…”

Section: Pathways For Transporting Substances Over the Bbbmentioning

confidence: 99%

Customizing delivery nano-vehicles for precise brain tumor therapy

et al. 2023

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Although some tumor has become a curable disease for many patients, involvement of the central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a special structure in the CNS, protects the brain from bloodborne pathogens via its excellent barrier properties and hinders new drug development for brain tumor. Recent breakthroughs in nanotechnology have resulted in various nanovehicless (NPs) as drug carriers to cross the BBB by different strategys. Here, the complex compositions and special characteristics of causes of brain tumor formation and BBB are elucidated exhaustively. Additionally, versatile drug nanovehicles with their recent applications and their pathways on different drug delivery strategies to overcome the BBB obstacle for anti-brain tumor are briefly discussed. Customizing nanoparticles for brain tumor treatments is proposed to improve the efficacy of brain tumor treatments via drug delivery from the gut to the brain. This review provides a broad perspective on customizing delivery nano-vehicles characteristics facilitate drug distribution across the brain and pave the way for the creation of innovative nanotechnology-based nanomaterials for brain tumor treatments.

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Section: Pathways For Transporting Substances Over the Bbbmentioning

confidence: 99%

Customizing delivery nano-vehicles for precise brain tumor therapy

et al. 2023

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“…Multidrug and antimicrobial extrusion protein (MATE), ATP Binding cassette transporter (ABC) and Small multidrug resistance (SMR) [25]. All bacteria contain several efflux pumps, which extrude not only antibiotic substrates but also non-antibiotic substrates such as heavy metals, dyes, detergents and organic solvents [26][27][28].…”

Section: A C C E T E Dmentioning

confidence: 99%

Analysis of antibiotic resistance genes in pig feces during the weaning transition using whole metagenome shotgun sequencing

Keum¹,

Kim²,

Cho³

et al. 2023

J Anim Sci Technol

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Upload this completed form to website with submission ARTICLE INFORMATION Fill in information in each box below Article Type Short CommunicationArticle Title (within 20 words without abbreviations) Analysis of antibiotic resistance genes in pig feces during the weaning transition using whole metagenome shotgun sequencing Running Title (within 10 words)Analysis of antibiotic resistance genes in weaned pigs

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“…The chameleonic nature of naphthalenoid ansamycins is important not only for transportation and binding with the target but can be essential from a bacteria resistance viewpoint, via increased/decreased affinity to efflux pump systems. 44,63,64 The zwitterionization phenomenon for naphthalenoid ansamycins as rifamycins have also impact on their polymorphism in the crystal state, which is a very important problem discussed at potential pharmaceutical applications of this group of macrolactams in the treatment of bacterial infections (including tuberculosis). 52,65–69…”

Section: Structural Aspects Of Naphthalenoid Ansamycins Influencing T...mentioning

confidence: 99%

Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins

Skrzypczak

Przybylski

2022

Nat. Prod. Rep.

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Efflux pumps potential drug targets to circumvent drug Resistance – Multi drug efflux pumps of Helicobacter pylori

Cited by 12 publications

References 50 publications

Customizing delivery nano-vehicles for precise brain tumor therapy

Customizing delivery nano-vehicles for precise brain tumor therapy

Analysis of antibiotic resistance genes in pig feces during the weaning transition using whole metagenome shotgun sequencing

Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins

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