Green-Inspired Fabrication of Silver Nanoparticles and Examine its Potential In-Vitro Cytotoxic and Antibacterial Activities

Muthusamy, Natarajan; Paulkumar, Kanniah; Murugan, Umavanitha; Raj, Divya S.; Umamaheswari, S.

doi:10.1007/s10904-021-02082-2

Cited by 8 publications

(3 citation statements)

References 91 publications

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“…According to the results of the fluorescence microscopic study, the VC-AgNPs could be used as an efficient cancer therapy agent. Similarly, previous studies that involved AgNPs synthesized through Cleome viscosa L fruit extracts (Lakshmanan et al, 2018), Terminalia chebula seed extracts (Muthusamy et al, 2021), and Annona muricata extracts (Jabir et al, 2021) have also reported the nuclear fragmentation of cancer cells after treatment with AgNPs, indicating the value of DAPI staining to study the photodynamic effect at the nuclear level.…”

Section: Fluorescence Microscopic Analysis Of Nuclear Fragmentation -...mentioning

confidence: 53%

Anticancer Potential of Vernonia cinerea Mediated AgNPs Against the Human Pancreatic Cancer PANC

et al. 2023

Intern. J. Zool. Invest.

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Vernonia cinerea (L.) Less is used in folk medicine as a remedy for various diseases. In vitro anticancer activity of green synthesized silver nanoparticles from the aqueous extract of V. cinerea extract was evaluated in the present study. Physicochemical characterization of the V. cinerea synthesized silver nanoparticles (VC-AgNPs) was performed using UV-analysis, FT-IR, SEM, XRD and DLS followed by the evaluation of anticancer activity on human pancreatic Cancer PANC. The nanoparticles were found to be spherical with a 50 nm average particle size and a zeta potential value of −18.6 mV. Silver nanoparticles exhibited significant toxicity to human pancreatic Cancer PANC with an IC50 value of 20.4 µg/ml. Following that, morphological alterations related with apoptosis were observed using acridine orange and ethidium bromide staining (AO/EtBr) with various doses of VC-AgNPs. The nanoparticles induced DNA fragmentation and also inhibited cell proliferation in PANC. In the PANC, the cytotoxic efficacy of VC-AgNPs was shown to be in dose dependant manner. Using florescence analysis, the effect of VC-AgNPs on cell cycle arrest was studied. The developed VC-AgNPs exerted potential anticancer activity on human pancreatic Cancer PANC.

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Section: Fluorescence Microscopic Analysis Of Nuclear Fragmentation -...mentioning

confidence: 53%

Anticancer Potential of Vernonia cinerea Mediated AgNPs Against the Human Pancreatic Cancer PANC

et al. 2023

Intern. J. Zool. Invest.

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“…The biocompatibility was tested with the McCoy fibroblast cell line, where 100 μg mL −1 (IC 50 – 67.26 μg mL −1 ) showed high inhibition along with apoptosis and nuclear fragmentation causing apoptosis. 80 …”

Section: Resultsmentioning

confidence: 99%

Evaluation of the biological responses of silver nanoparticles synthesized using Pelargonium x hortorum extract

Lopez-Ayuso,

Garcia-Contreras,

Manisekaran

et al. 2023

RSC Adv.

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“…The research indicates that silver nanoparticles may be reduced and capped due to the presence of phytoconstituents [27]. The FTIR examination of silver nanoparticles synthesized from T. chebula seed extract was published in another work [28]; however, the particular peaks identified were not specified. Previous studies found that silver nanoparticles mediated by Aspergillus niger exhibited unique peaks at 548.38 cm −1 , 1636.17 cm −1 , and 3347.85 cm −1 [29].…”

Section: Ft-irmentioning

confidence: 99%

Terminalia chebula-Assisted Silver Nanoparticles: Biological Potential, Synthesis, Characterization, and Ecotoxicity

et al. 2023

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In the current research, an aqueous extract of Terminalia chebula fruit was used to produce silver nanoparticles (Ag NPs) in a sustainable manner. UV-visible spectrophotometry, transmission electron microscopy (TEM), and scanning electron microscopy (SEM) were used to characterize the synthesized nanoparticles. Synthesized Ag NPs were detected since their greatest absorption peak was seen at 460 nm. The synthesized Ag NPs were spherical and had an average size of about 50 nm, with agglomerated structures, as shown via SEM and TEM analyses. The biological activities of the synthesized Ag NPs were evaluated in terms of their antibacterial and antioxidant properties, as well as protein leakage and time-kill kinetics assays. The results suggest that the green synthesized Ag NPs possess significant antibacterial and antioxidant activities, making them a promising candidate for therapeutic applications. Furthermore, the study also evaluated the potential toxicological effects of the Ag NPs using zebrafish embryos as a model organism. The findings indicate that the synthesized Ag NPs did not induce any significant toxic effects on zebrafish embryos, further supporting their potential as therapeutic agents. In conclusion, the environmentally friendly production of Ag NPs using the extract from T. chebula is a promising strategy for discovering novel therapeutic agents with prospective uses in biomedicine.

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Green-Inspired Fabrication of Silver Nanoparticles and Examine its Potential In-Vitro Cytotoxic and Antibacterial Activities

Cited by 8 publications

References 91 publications

Anticancer Potential of Vernonia cinerea Mediated AgNPs Against the Human Pancreatic Cancer PANC

Anticancer Potential of Vernonia cinerea Mediated AgNPs Against the Human Pancreatic Cancer PANC

Evaluation of the biological responses of silver nanoparticles synthesized using Pelargonium x hortorum extract

Terminalia chebula-Assisted Silver Nanoparticles: Biological Potential, Synthesis, Characterization, and Ecotoxicity

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