Substituents 4298 III. Carbohydrate Ligands without Donor Groups 4299 A. Anionic Carbohydrate Ligands 4299 1. Carbohydrate Carbanions 4299 2. Carbohydrate Diolato Ligands 4300 B. Neutral Carbohydrate Ligands 4301 1. Platinum(IV) Complexes with Monoprotected Carbohydrate Ligands 4301 2. Platinum Complexes with Diprotected Carbohydrate Ligands 4303 3. Platinum Complexes with Glucopyranoside and Acetylated Carbohydrate Ligands 4304 4. Platinum Complexes with Nonprotected Carbohydrate Ligands 4304 5. Characterization of Carbohydrate Platinum(IV) Complexes 4305 IV. Sugar Alcohol and Sugar Acid Ligands 4305 A. Sugar Alcohol Ligands 4305 1. Sugar Alcohols without Donor Groups 4305 2. Sugar Alcohols with Donor Groups 4306 3. Diolato Ligands 4307 B. Sugar Acid Ligands 4309 V. Cyclodextrin Complexes 4311 A. Inclusion Compounds 4311 B. Cyclodextrins with Donor Groups 4313 VI. Conclusion 4314 VII. Abbrevations 4315 VIII. Acknowledgments 4315 IX. References 4315

The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death.

New platinum(IV)-coordinated carbohydrate complexes [PtMe 3 L]BF 4 (14E-21E, 22D-24D) have been prepared from the reaction of [PtMe 3 (Me 2 CO) 3 ]BF 4 (1) with a wide range of isopropylidene-protected carbohydrates L′ in acetone. These complexation reactions can be accompanied by a platinum-promoted cleavage of an isopropylidene group (14E, L′ )

Summary:  Hexachloroplatinic acid reacts with n-butanol to give the but-2-ene complex H[PtCl3(η2-C4H8)] (3) as intermediate, which reacts with trimethylsilyl-substituted acetylenes R‘C⋮CSiMe3 (R‘ = H, Me, SiMe3) with cleavage of the silyl groups to form platina-β-diketones [Pt2(μ-Cl)2{(COR)2H}2] [R = Me (2a), Et (2b)]. The constitution of 2 was determined by microanalysis, NMR (1H, 13C) spectroscopy, IR, Raman, and mass spectroscopy. The structure of 2a was determined by X-ray diffraction.