Carbohydrate Complexes of Platinum-Group Metals

Abstract

Substituents 4298 III. Carbohydrate Ligands without Donor Groups 4299 A. Anionic Carbohydrate Ligands 4299 1. Carbohydrate Carbanions 4299 2. Carbohydrate Diolato Ligands 4300 B. Neutral Carbohydrate Ligands 4301 1. Platinum(IV) Complexes with Monoprotected Carbohydrate Ligands 4301 2. Platinum Complexes with Diprotected Carbohydrate Ligands 4303 3. Platinum Complexes with Glucopyranoside and Acetylated Carbohydrate Ligands 4304 4. Platinum Complexes with Nonprotected Carbohydrate Ligands 4304 5. Characterization of Carbohydrate Platinum(IV) Complexes 4305 IV. Sugar Alcohol and Sugar Acid Ligands 4305 A. Sugar Alcohol Ligands 4305 1. Sugar Alcohols without Donor Groups 4305 2. Sugar Alcohols with Donor Groups 4306 3. Diolato Ligands 4307 B. Sugar Acid Ligands 4309 V. Cyclodextrin Complexes 4311 A. Inclusion Compounds 4311 B. Cyclodextrins with Donor Groups 4313 VI. Conclusion 4314 VII. Abbrevations 4315 VIII. Acknowledgments 4315 IX. References 4315

Crystal structure of 4,8-di(acetoxy)-2,6-dioxabicyclo[3.3.0]octane-3,7-dione (O2,O5-diacetylglucaric acid-1,4:6,3-dilactone), C10H10O8

“…Due to manifold donor sites of nearly equivalent weakly donating oxygen atoms, the coordination behavior of carbohydrates and carbohydrate derivatives is strongly dependent on the carbohydrate conformation [1,2]. In this respect the solid state structure of the title compound is of interest.…”

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

“…Cyclopentadienyl-titanium complexes with chiral σ-coordinated ligands derived from glucose are stereoselective reagents in organic synthesis [244,245]. A large number of chiral ligands derived from carbohydrates, mainly phosphines, are used in asymmetric catalysis [246][247][248]. The trimethylplatinum(IV) cation proved to be very well suited for the coordination of unprotected monosacharides (Scheme 1.26) [248].…”

“…A large number of chiral ligands derived from carbohydrates, mainly phosphines, are used in asymmetric catalysis [246][247][248]. The trimethylplatinum(IV) cation proved to be very well suited for the coordination of unprotected monosacharides (Scheme 1.26) [248].…”

Synthesis and Antibacterial Activities of Sugar-containing Platinum Ethynyl Complexes

“…One general principle used in nature is the attachment of biomolecules to active species to obtain binding domains, transport systems and enzyme activities. Monosaccharides are fundamental biomolecules, and they are the constitutional parts of complex lipids (glycolipids) and proteins (glycoproteins) and nucleic acid (Steinborn et al 2000). The attachment of glycosidically bound carbohydrate moieties to metal ions may be a suitable option to create new materials with combined properties of both building blocks: carbohydrates and metal complexes (Wegner et al 2001, Gottschaldt et al 2009, Gottschaldt et al 2004.…”

“…Introduction of sugar atom into the biological materials not only increases the solubility, but also influences their biocompatibility, primarily, acting as energy source and contributing to various recognition or specific transformation processes. Carbohydrate complexes of platinum group metals (Pd, Pt, Rh, Ir), where carbohydrate is directly bonded to metal atom, have been reported (Steinborn et al 2000). In recent years, metal coordination complexes with sugar substituted chelating ligands were studied for the development of diagnostic tracers (Mindt et al 2006, Ferreira et al 2006, MRI contrast agents (Fulton et al 2006, Duimstra et al 2005 and therapeutic agents (Krishnamurthy et al 2008, Ott et al 2005, Ma et al 2005.…”