A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

Jaouen, Gérard; Beck, Wolfgang; McGlinchey, Michael J.

doi:10.1002/3527607692.ch1

Cited by 28 publications

(20 citation statements)

References 171 publications

(215 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[46] In contrast, bio-organometallic chemistry is a more recent, but now burgeoning, field in which organometallic moieties are incorporated into biologically active molecules. [47] The term was apparently first used in 1985 to describe molecules containing metal carbonyl fragments pbonded to an aromatic ring of a steroid, as in (estradiol)Cr(CO) 3 . [48] The idea was to use the natural hormone, in this case estradiol, to transport a label to, and thereby assay, the receptor sites by measuring the intensity of the very strong metal carbonyl, u CO , infrared vibrations between 2100 and 1850 cm À1 ; this frequency range is compatible with a window in which the proteins do not absorb.…”

Section: Cyclophanes In Bio-organometallic Chemistrymentioning

confidence: 99%

From [10]Paracyclophane to Ferrocenophanones: The Search for Molecular Machines and Bio‐Organometallic Anticancer Drugs

McGlinchey¹,

Milosevic²

2011

Israel Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

A partial quenching of the NMR ring current in [10]paracyclophane‐chromium tricarbonyl prompted a study of other metal–arene π complexes, several of which exhibited restricted intramolecular motion relevant to their potential use in molecular machines. An attempted Diels–Alder reaction of 9‐phenylethynyl‐9H‐fluorene with tetracyclone instead yielded a novel tetracene by isomerization of the alkyne to the corresponding allene, and then via a series of allene dimers which are classifiable as cyclophanes. (Subsequently, the first organometallic molecular brake was prepared, whereby migration of a metal carbonyl tripod over an indenyl framework blocked the rotation of a triptycene paddlewheel.) Cyclophanes have now found applicability in the field of bio‐organometallic chemistry; the activity of tamoxifen, the first line treatment for hormone‐dependent breast cancers, is markedly enhanced when the structure is modified by incorporation of a ferrocenophane moiety. Finally, we relate the story of how the first cyclophane, [1.1.1]orthocyclophane, was actually prepared by Cannizzaro in 1854, but was only recognized as such more than 150 years later.

show abstract

Section: Cyclophanes In Bio-organometallic Chemistrymentioning

confidence: 99%

From [10]Paracyclophane to Ferrocenophanones: The Search for Molecular Machines and Bio‐Organometallic Anticancer Drugs

McGlinchey¹,

Milosevic²

2011

Israel Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…On top of that, some transition metal complexes are required to be handled with care due to their air-and moisture-sensitivity and toxicity issues. Nevertheless, there are also many classes of transition metal complexes that are sufficiently stable in air and water, and employable in biological systems [9,10]. In fact, some of them have been successfully translated to clinical uses.…”

Section: Introductionmentioning

confidence: 99%

Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging

Kong¹,

Liao²,

Goh³

et al. 2014

J Nanomed Nanotechnol

View full text Add to dashboard Cite

show abstract

“…Although it was less toxic, containing only 19% arsenic [2] , neoarsphenamine was nonetheless associated with side-effects such as nausea and vomiting. An additional problem was that both Salvarsan and Neosalvarsan had to be stored in sealed vials under a nitrogen atmosphere to prevent oxidation [26] .…”

Section: Salvarsan the First Successful Chemotherapeutic Drugmentioning

confidence: 99%

The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize

2008

View full text Add to dashboard Cite

On the centenary of Paul Ehrlich’s Nobel Prize, this German researcher deserves to be remembered as a pioneer in a large number of scientific disciplines. As a result of his enthusiasm and scientific abilities, dedication, and contacts with other scientists of his time, he was able to make countless contributions in fields as diverse as histology, haematology, immunology, oncology, microbiology and pharmacology, among others. Although the Swedish award was meant to recognize the standardization of the manufacture of antidiphtheria serum, it was the discovery of arsphenamine (Salvarsan) for the treatment of syphilis which won him wider international acclaim. From a pharmacological perspective, Ehrlich’s outstanding contributions include dissemination of the ‘magic bullet’ concept for the synthesis of antibacterials, introduction of concepts such as chemoreceptor and chemotherapy, and linking the chemical structure of compounds to their pharmacological activity. These achievements took place within the framework he established for the transition from experimental pharmacology to therapeutic pharmacology. He introduced a modern research system based on the synthesis of multiple chemical structures for pharmacological screening in animal models of disease states. These contributions were undoubtedly decisive in propitiating the wider development of antibiotics decades later. For these reasons, it is fitting to mark the 100th anniversary of the Nobel Prize awarded to this great scientist by commemorating the importance of his contributions to the advance of pharmacology.

show abstract

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

Cited by 28 publications

References 171 publications

From [10]Paracyclophane to Ferrocenophanones: The Search for Molecular Machines and Bio‐Organometallic Anticancer Drugs

From [10]Paracyclophane to Ferrocenophanones: The Search for Molecular Machines and Bio‐Organometallic Anticancer Drugs

Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging

The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize

Contact Info

Product

Resources

About