Anak yang mengalami obesitas pada usia pra pubertas memiliki tinggi badan di atasrata-rata anak seusianya. Penelitian mengenai hal ini menunjukkan bahwa anakmengalami masa pacu tumbuh yang lebih awal namun saat proses pertumbuhan hampirselesai kecepatan tersebut akan berkurang relatif dibandingkan anak normal, sehinggatinggi badan akhir anak saat dewasa tetap sama dengan rata-rata tinggi badan orangtuanya atau bahkan lebih pendek bila dibandingkan dengan anak yang tidak mengalamiobesitas pada masa pertumbuhannya. Dijumpai abnormalitas pada hormon yang berperandalam pertumbuhan linier pada anak yang mengalami obesitas yaitu pada aksis GHIGF,hormon seks steroid, dan glukokortikoid.
Background Spleen is an important organ in immunity to malariainfection which is always affected in malaria patients. Enlargementof the spleen is one of the main clinical symptoms of malaria. Levelof parasitemia is related to the risk of complications.Objective To describe the correlation between parasitemia andspleen size in patients with P.falciparum infection.Methods One hundred and four patients including children andadults with fever, pale, jaundice, diarrhea, and headache who vis-ited public health centers in 5 villages in Mandailing Natal, NorthSumatera were enrolled in this study. The diagnosis of malariawas based on blood smears stained by Giemsa method, while thespleen size was measured using Hackett method. Correlation be-tween parasitemia and spleen size was tested by Spearman rankcorrelation.Results Splenomegaly was found in 37 of 104 patients (35.6 %)with the size of H1 in 10.6 %, H2 in 15.4 %, H3 in 9.6 %. The meanparasite count between patients with and without splenomegalywas different, and the difference was significant between patientswith spleen size of H0 and H3. The higher the parasitemia, thebigger the spleen size was (r=0.291; p=0.03).Conclusion There was a correlation between parasitemia andspleen size in falciparum malarial infection
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