Short- and long-chain perfluoroalkyl acids (PFAAs), ubiquitously coexisting in the environment, can be accumulated in organisms by binding with proteins and their binding affinities generally increase with their chain length. Therefore, we hypothesized that long-chain PFAAs will affect the bioconcentration of short-chain PFAAs in organisms. To testify this hypothesis, the bioconcentration and tissue distribution of five short-chain PFAAs (linear C-F = 3-6) were investigated in zebrafish in the absence and presence of six long-chain PFAAs (linear C-F = 7-11). The results showed that the concentrations of the short-chain PFAAs in zebrafish tissues increased with exposure time until steady states reached in the absence of long-chain PFAAs. However, in the presence of long-chain PFAAs, these short-chain PFAAs in tissues increased until peak values reached and then decreased until steady states, and the uptake and elimination rate constants of short-chain PFAAs declined in all tissues and their BCF decreased by 24-89%. The inhibitive effect of long-chain PFAAs may be attributed to their competition for transporters and binding sites of proteins in zebrafish with short-chain PFAAs. These results suggest that the effect of long-chain PFAAs on the bioconcentration of short-chain PFAAs should be taken into account in assessing the ecological and environmental effects of short-chain PFAAs.
Warming and exposure to emerging global pollutants, such
as per-
and polyfluoroalkyl substances (PFAS), are significant stressors in
the aquatic ecosystem. However, little is known about the warming
effect on the bioaccumulation of PFAS in aquatic organisms. In this
study, the pelagic organisms Daphnia magna and zebrafish, and the benthic organism Chironomus
plumosus were exposed to 13 PFAS in a sediment–water
system with a known amount of each PFAS at different temperatures
(16, 20, and 24 °C). The results showed that the steady-state
body burden (C
b‑ss) of PFAS in
pelagic organisms increased with increasing temperatures, mainly attributed
to increased water concentrations. The uptake rate constant (k
u) and elimination rate constant (k
e) in pelagic organisms increased with increasing temperature.
In contrast, warming did not significantly change or even mitigate C
b‑ss of PFAS in the benthic organism Chironomus plumosus, except for PFPeA and PFHpA,
which was consistent with declined sediment concentrations. The mitigation
could be explained by the decreased bioaccumulation factor due to
a more significant percent increase in k
e than k
u, especially for long-chain PFAS.
This study suggests that the warming effect on the PFAS concentration
varies among different media, which should be considered for their
ecological risk assessment under climate change.
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