An unexpected synergistic toxicity caused by competitive bioconcentration of perfluoroalkyl acid mixtures to Daphnia magna: Further promoted by elevated temperature

Zhang, Qianru; Zhang, Yidi; Hu, Diexuan; Wen, Wu; Xia, Xinghui

doi:10.1016/j.envpol.2022.120336

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…This slight underestimation might be attributed to the mixed PFAS exposure used in this study, leading to competition among the PFAS with different carbon chain lengths and structures when binding to the limited protein cavity sites. 73 Similarly, the weaker binding affinity of PFOA to liver fatty acid binding protein (

) than PFOS (

) may account for its lower PL under mixed PFAS exposure in this study than that exposed to PFOA alone in previous studies. 72 , 74 , 75 …”

Section: Discussionmentioning

confidence: 57%

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models

Zhu,

Pan,

Jia

et al. 2023

Environ Health Perspect

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Background: Oral ingestion, inhalation, and skin contact are important exposure routes for humans to uptake per- and polyfluoroalkyl substances (PFAS). However, nasal and dermal exposure to PFAS remains unclear, and accurately predicting internal body burden of PFAS in humans via multiple exposure pathways is urgently required. Objectives: We aimed to develop multiple physiologically based toxicokinetic (PBTK) models to unveil the route-specific pharmacokinetics and bioavailability of PFAS via respective oral, nasal, and dermal exposure pathways using a mouse model and sought to predict the internal concentrations in various tissues through multiple exposure routes and extrapolate it to humans. Methods: Mice were administered the mixed solution of perfluorohexane sulfonate, perfluorooctane sulfonate, and perfluorooctanoic acid through oral, nasal, and dermal exposure separately or jointly. The time-dependent concentrations of PFAS in plasma and tissues were determined to calibrate and validate the individual and combined PBTK models, which were applied in single- and repeated-dose scenarios. Results: The developed route-specific PBTK models successfully simulated the tissue concentrations of PFAS in mice following single or joint exposure routes as well as long-term repeated dose scenarios. The time to peak concentration of PFAS in plasma via dermal exposure was much longer (34.1–83.0 h) than that via nasal exposure (0.960 h). The bioavailability of PFAS via oral exposure was the highest (73.2%–98.0%), followed by nasal (33.9%–66.8%) and dermal exposure (4.59%–7.80%). This model was extrapolated to predict internal levels in human under real environment. Discussion: Based on these data, we predict the following: PFAS were absorbed quickly via nasal exposure, whereas a distinct hysteresis effect was observed for dermal exposure. Almost all the PFAS to which mice were exposed via gastrointestinal route were absorbed into plasma, which exhibited the highest bioavailability. Exhalation clearance greatly depressed the bioavailability of PFAS via nasal exposure, whereas the lowest bioavailability in dermal exposure was because of the interception of PFAS within the skin layers. https://doi.org/10.1289/EHP11969

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) than PFOS (

) may account for its lower PL under mixed PFAS exposure in this study than that exposed to PFOA alone in previous studies. 72 , 74 , 75 …”

Section: Discussionmentioning

confidence: 57%

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models

Zhu,

Pan,

Jia

et al. 2023

Environ Health Perspect

View full text Add to dashboard Cite

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Co-exposure to microplastic and plastic additives causes development impairment in zebrafish embryos

Kim,

Zee

et al. 2024

Aquatic Toxicology

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Fractionation of perfluoroalkyl acids (PFAAs) along the aquatic food chain promoted by competitive effects between longer and shorter chain PFAAs

Wen

Xiao

et al. 2023

Chemosphere

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An unexpected synergistic toxicity caused by competitive bioconcentration of perfluoroalkyl acid mixtures to Daphnia magna: Further promoted by elevated temperature

Cited by 6 publications

References 41 publications

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models

Co-exposure to microplastic and plastic additives causes development impairment in zebrafish embryos

Fractionation of perfluoroalkyl acids (PFAAs) along the aquatic food chain promoted by competitive effects between longer and shorter chain PFAAs

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