Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content

Wen, Wu; Xia, Xinghui; Zhou, Dong; Wang, Haotian; Zhai, Yuanzheng; Lin, Hui; Chen, Jian; Hu, Diexuan

doi:10.1016/j.envpol.2019.03.003

Cited by 57 publications

(27 citation statements)

References 51 publications

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“…As shown in Table 4, the BCF of some organisms in Xiamen freshwater and seawater was listed. e values of [27], and 1.8 × 10 3 in zebrafish [41]. However, the BCF of PFOA in this study is much higher than that reported before.…”

Section: Pfa Distribution In Organisms As Shown Incontrasting

confidence: 60%

“…However, the BCF of PFOA in this study is much higher than that reported before. According to the literature, the BCF of PFOA is 4 in rainbow trout [41] and 3.1∼9.4 in carp [9]. e previous studies indicated that only the PFAs with the carbon chain length more than 7 could accumulate in organism, and the BCF increases with the increasing carbon chain length [42].…”

Section: Pfa Distribution In Organisms As Shown Inmentioning

confidence: 98%

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Distribution and Bioaccumulation of Perfluoroalkyl Acids in Xiamen Coastal Waters

Dai

Zeng²

2019

Journal of Chemistry

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Since perfluoroalkyl acids (PFAs) are widely used and harmless to organisms, they have attracted great attention in recent years. e distribution of PFAs in the oceans all around the world is well documented. However, the study of PFAs in Xiamen could be a beneficial complement, for its unique geologies of no rivers that originate from other cities to influence the concentration of PFAs in this area. In this paper, six PFAs were analyzed in water, sediments, and organisms from both freshwater and seawater and the bioaccumulation factors (BAFs) were calculated with the quantity of PFAs in different trophic levels of aquatic organisms. e results showed that the ΣPFA concentrations ranged from 7.66 to 11.98 ng·L − 1 for seawater samples and from 2.12 to 8.61 ng·L − 1 for freshwater. e concentration of ΣPFAs in sediments was 7.43-12.89 ng·g − 1 and 4.53-5.80 ng·g − 1 in seawater and freshwater, respectively. e PFA concentration in water is highly positive correlated with the PFA concentration in sediments (R 2 � 0.85). e calculated bioaccumulation factors (BCFs) were 6412-14254 L·kg − 1 and 2927-7959 L·kg − 1 for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonates (PFOS), respectively. PFOA seems more bioaccumulative than PFOS in seawater. e results illustrated the PFA pollution in the Xiamen sea area, and it is useful for the protection and control of the organic pollutants in this area.

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Section: Pfa Distribution In Organisms As Shown Incontrasting

confidence: 60%

Section: Pfa Distribution In Organisms As Shown Inmentioning

confidence: 98%

Distribution and Bioaccumulation of Perfluoroalkyl Acids in Xiamen Coastal Waters

Dai

Zeng²

2019

Journal of Chemistry

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“…Dendron topology was selected to control the homogeneity of the structure and particularly taking into account the possible dendronization processes over other platforms, such as nanoparticles, polymers or drugs. In addition, perfluorinated derivatives were chosen based on their well-known chain length-bioaccumulation relationship-the limit was established in six perfluorinated carbons to be considered as non-bioaccumulative compounds [19][20][21]. All employed fluorinated precursors for the dendron functionalization used in this work and are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Scheme 5, this synthetic route involves the initial incorporation of 1H, 1H, 2H,2Hperfluorooctanethiol over superficial allyl groups of the dendritic precursor with the phtalimide unit at the focal point PhGnAm (n = 2, m = 4 (v); n = 3, m = 8 (vi)) [28] in a ratio 1:y, yielding statistical decoration in the dendrimers due to the equal reactivity of the allyl groups [21], and the subsequent functionalization of the rest of allyl groups with sodium 3-mercapto-1-propanesulfonate. The thiolene functionalization of the surface was carried out in 4 h by a photocatalytic process using 2,2dimethoxy-2-phenylacetophenone (DMPA) as photoinitiator.…”

Section: Dendrons With Perfluorinated Chains At the Peripherymentioning

confidence: 99%

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

et al. 2020

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The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.

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“…Brinkman et al (2016) have reported that the bioconcentration potential of many neutral organic chemicals was proportional to their lipophilicity. Previous studies have also found that 8:2 diPAP is a hydrophobic organic contaminant that accumulates mainly in adipose tissues (Wang et al 2011;Wen et al 2019). The hydrophobicity of 8:2 diPAP may be a reason for its preferential accumulation in the digestive gland.…”

Section: Tissue Distributionmentioning

confidence: 95%

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

Cui

Tan

Chen

et al. 2021

Enviro Toxic and Chemistry

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Although the distribution of 8:2 polyfluoroalkyl phosphate diester (8:2 diPAP) in aquatic environments has been reported, details on its uptake, tissue specificity, and elimination in bivalve mollusks remain to be clarified. The present study is the first report on the accumulation and elimination of 8:2 diPAP in mussels (Mytilus galloprovincialis). The tissue-specific accumulation and depuration of 8:2 diPAP and its metabolites were investigated via semistatic seawater exposure (8:2 diPAP at a nominal concentration of 10 μg/L), through water-borne exposure with static daily renewal over a 72-h exposure period and a 360-h depuration period. The digestive gland was found to be the target organ where accumulation and biotransformation primarily occur. The bioaccumulation factor values (mL/g dry wt) in different organs were in the following order: digestive gland (1249) > adductor muscle (315) > gills (289) > gonad (82.9) > mantle (33.0). Moreover, the distribution of 8:2 diPAP among tissues may be related to the total protein content. The 8:2 diPAP tended to be excreted in feces. The compounds 8:2 fluorotelomer carboxylic acid, 8:2 fluorotelomer unsaturated carboxylic acid, 7:3 fluorotelomer carboxylic acid, perfluorooctanoic acid, and perfluoroheptanoic acid were detected and quantified as phase I metabolites, and the concentration of all phase I metabolites relative to the 8:2 diPAP concentration (72 h) was 0.304 mol%. A phase II metabolite, 8:2 fluorotelomer alcohol conjugated with sulfate, was detected but not quantitated in the digestive gland. A biotransformation pathway of 8:2 diPAP in M. galloprovincialis was proposed on the basis of the results obtained in the present study and previous studies. These findings improve our understanding of the accumulation of perfluorocarboxylic acids in bivalve mollusks.

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Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content

Cited by 57 publications

References 51 publications

Distribution and Bioaccumulation of Perfluoroalkyl Acids in Xiamen Coastal Waters

Distribution and Bioaccumulation of Perfluoroalkyl Acids in Xiamen Coastal Waters

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis

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