New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Mencia, Gabriel; Lozano-Cruz, Tania; Valiente, Mercedes; Mata, Javier de la; Cano, Jesús; Gómez, Rafael

doi:10.3390/molecules25040807

Cited by 7 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study, Mencia et al [80] . adopted a simple method to prepare novel ionic carbosilane dendrons by bonding fluorinated units at different locations in different molecular skeletons.…”

Section: Construction Of Nanoprobes For 19f Mri‐synergized Cancer Man...mentioning

confidence: 99%

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Cui

et al. 2022

ChemMedChem

View full text Add to dashboard Cite

Fluorine magnetic resonance imaging (19F MRI) is a promising imaging technique for cancer diagnosis because of its excellent soft tissue resolution and deep tissue penetration, as well as the inherent high natural abundance, almost no endogenous interference, quantitative analysis, and wide chemical shift range of the 19F nucleus. In recent years, scientists have synthesized various 19F MRI contrast agents. By further integrating a wide variety of nanomaterials and cutting‐edge construction strategies, magnetically equivalent 19F atoms are super‐loaded and maintain satisfactory relaxation efficiency to obtain high‐intensity 19F MRI signals. In this review, the nuclear magnetic resonance principle underlying 19F MRI is first described. Then, the construction and performance of various fluorinated contrast agents are summarized. Finally, challenges and future prospects regarding the clinical translation of 19F MRI nanoprobes are considered. This review will provide strategic guidance and panoramic expectations for designing new cancer theranostic regimens and realizing their clinical translation.

show abstract

Section: Construction Of Nanoprobes For 19f Mri‐synergized Cancer Man...mentioning

confidence: 99%

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Cui

et al. 2022

ChemMedChem

View full text Add to dashboard Cite

show abstract

“…This chemically stable fluorine‐containing dendron scaffold was available for further chemical modifications on the surface, for instance for grafting cationic derivatives. However, the CMC value of this dendron was very high, above 1 mM [126] …”

Section: Amphiphilic Dendrons Containing Main Group Elementsmentioning

confidence: 84%

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Apartsin

Caminade

2021

Chemistry A European J

View full text Add to dashboard Cite

This review presents precisely defined amphiphilic dendrons, their self‐association properties, and their different uses. Dendrons, also named dendritic wedges, are composed of a core having two different types of functions, of which one type is used for growing or grafting branched arms, generally multiplied by 2 at each layer by using 1→2 branching motifs. A large diversity of structures has been already synthesized. In practically all cases, their synthesis is based on the synthesis of known dendrimers, such as poly(aryl ether), poly(amidoamine) (in particular PAMAM), poly(amide) (in particular poly(L‐lysine)), 1→3 branching motifs (instead of 1→2), poly(alkyl ether) (poly(glycerol) and poly(ethylene glycol)), poly(ester), and those containing main group elements (poly(carbosilane) and poly(phosphorhydrazone)). In most cases, the hydrophilic functions are on the surface of the dendrons, whereas one or two hydrophobic tails are linked to the core. Depending on the structure of the dendrons, and on the experimental conditions used, the amphiphilic dendrons can self‐associate at the air‐water interface, or form micelles (eventually tubular, but most generally spherical), or form vesicles. These associated dendrons are suitable for the encapsulation of low‐molecular or macromolecular bioactive entities to be delivered in cells. This review is organized depending on the nature of the internal structure of the amphiphilic dendrons (aryl ether, amidoamine, amide, quaternary carbon atom, alkyl ether, ester, main group element). The properties issued from their self‐associations are described all along the review.

show abstract

“…Fluorine-containing amphiphilic CBS dendrons were synthetized with perfluorinated alkyl chains as the hydrophobic part and ammonium groups in the hydrophilic side (Mencía, Lozano-Cruz, Valiente, de la Mata, et al, 2020). Fluorine atoms increase hydrophobicity in the molecules favoring the interaction with biological membranes and increasing biocompatibility.…”

Section: Supramolecular Dendritic Assembliesmentioning

confidence: 99%

Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications

Mata

Gomez-Ramirez

Cano

et al. 2022

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Dendrimers are multifunctional molecules with well‐defined size and structure due to the step‐by‐step synthetic procedures required in their preparation. Dendritic constructs based on carbosilane scaffolds present carbon–carbon and carbon–silicon bonds, which results in stable, lipophilic, inert, and flexible structures. These properties are highly appreciated in different areas, including the pharmaceutical field, as they can increase the interaction with cell membranes and improve the therapeutic action. This article summarizes the most recent advances in the pharmaceutical applications of carbosilane dendritic molecules, from therapeutics to diagnostics and prevention tools. Dendrimers decorated with cationic, anionic, or other moieties, including metallodendrimers; supramolecular assemblies; dendronized nanoparticles and surfaces; as well as dendritic networks like hydrogels are described. The collected examples confirm the potential of carbosilane dendrimers and dendritic materials as antiviral or antibacterial agents; in therapy against cancer, neurodegenerative disease, or oxidative stress; or many other biomedical applications. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Cited by 7 publications

References 29 publications

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications

Contact Info

Product

Resources

About

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Cited by 7 publications

References 29 publications

19F MRI Nanotheranostics for Cancer Management: Progress and Prospects

19F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications

Contact Info

Product

Resources

About

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects