Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan. The difficulty in identification, incorrect use of antifungal drugs, and treatment failure are causes of high mortality. Since then, C. auris has been increasingly reported from East Asia to North America, with substantial fatalities and misidentification. This review aims at describing the epidemiology, virulence, risk factors, resistance, and therapeutic options in C. auris infections.
Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor κB activation, tumor necrosis factor α release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsisolis and reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food.
We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC). The antibiofilm potential was tested in mature biofilms formed by Candida species and analyzed through the counting of CFU/mL and scanning electron micrograph (SEM). In vivo toxicity and therapeutic action was evaluated in the Galleria mellonella model. The treatment with the extract, in low doses, was able to reduce the growth of planktonic cells of Candida species. MIC values range between 19.5 and 39 µg/mL and MFC values range between 79 and 625 µg/mL. In addition was able to reduce the number of CFU/mL in biofilms and to cause structural alteration and cellular destruction, observed via SEM. A. colubrina showed low toxicity in the in vivo assay, having not affected the viability of the larvae at doses below 100mg/kg and high potential in the treatment of C. albicans infection. Considering its high antifungal potential, its low toxicity and potential to treatment of infections in in vivo model, A. colubrina extract is a strong candidate for development of a new agent for the treatment of oral candidiasis.
ResumoObjetivo: Realizar um estudo bibliométrico dos resumos da SBPqO, traçando um perfil dos trabalhos publicados. Material e métodos: Realizou-se um estudo descritivo, analisando os resumos publicados em anais do referido evento. Os trabalhos foram classificados de acordo com ano de publicação; região; estado; instituição; tipo de instituição; objeto, área ou assunto estudado; tipo de estudo; caracterização do estudo; citação de submissão ao Comitê de Ética e Pesquisa; financiamento para realização da pesquisa; agência/órgão de fomento. A coleta foi realizada por três examinadores, que organizaram os resultados em um banco informatizado. Resultados: De um total de 8.381 resumos, 743 (8,86%) foram referentes à área endodôntica, sendo a maioria desenvolvida na região sudeste (66,1%), principalmente no estado de São Paulo (47%). Como assunto mais pesquisado destacou-se "limas, materiais e instrumentos", com 47,6%. Observou-se maior quantidade de estudos experimentais (66,1%), sendo os do tipo in vitro mais presentes (64,3%). A maioria das pesquisas foi advinda de instituições públicas (73,8%), principalmente de duas instituições específicas: USP com 14,8% e da UNESP com 13,5% dos trabalhos. Percebeu-se, ainda, uma grande quantidade de estudos realizados sem auxílio financeiro (68,5%). Não houve citação de submissão ao Comitê de Ética e Pesquisa. Conclusão: Constatou-se que existe o interesse científico pela área endodôntica mesmo que em pequena escala. Ao mesmo tempo, observou-se a necessidade de maior incentivo às pesquisas em alguns locais, visto que houve concentração em determinadas regiões e instituições, bem como uma diminuição das pesquisas ao considerar-se os anos analisados. Descritores: Pesquisa em Odontologia; Bibliometria; Endodontia. AbstractObjective: This study aimed to perform a comparative analysis of self-perception, the behaviors and attitudes of oral health and the oral health status of adult patients treated at the clinics of the Dentistry Graduate Course from the Dentristy Department of the Federal University of Rio Grande do Norte -UFRN. Methods: A sample of 36 patients was evaluated by applying a questionnaire about self-perception and oral hygiene habits, besides the evaluation of oral health status based on clinical examination data and obtaining the oral indices such as DMF, IVP and IGB. The Data was analyzed using descriptive statistics. Results: It was observed that 94.4% of patients reported having a poor oral health and only 5.6% believed they had adequate oral health. It was found that 41.7% of patients showed low DMFT and 21 (58.3%) high DMFT. A significant proportion of patients (61.8%) felt that having a poor oral health showed high DMFT. Most of the sample felt that having a poor gum health and VPI had a high moderate to severe degree of gingival inflammation. Conclusion: There was a correlation between selfrated oral health and oral clinical conditions of the population evaluated. The results suggest that self-perception of oral health may represent a useful tool in dentistry ...
Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado.Prevalência de erosão dentária e fatores associados em uma população de escolaresPrevalence of dental erosion and associated factors in a schoolchildren population ResumoIntrodução: Erosão dentária é a perda irreversível de tecido dentário, sem envolvimento bacteriano, cujo aumento de prevalência, nos últimos anos, tem sido alarmante. Objetivo: Determinar a prevalência de erosão dentária, bem como fatores associados, em escolares de 06 a 13 anos, na cidade de Campina Grande, Paraíba. Material e método: A seleção das escolas foi realizada por amostragem casual simples sem reposição. Após assinatura do Termo de Consentimento Livre e Esclarecido, e do Termo de Assentimento, os exames foram realizados por um examinador previamente calibrado, com a criança sentada em uma cadeira escolar, em frente ao examinador, sob luz natural. Para a determinação da presença e do grau de erosão dentária, foi utilizado o índice de BEWE. Os dados foram analisados por meio do software Statistical Package for the Social Sciences (SPSS para Windows, versão 18.0, SPSS Inc, Chicago, IL, EUA) e adotou-se nível de significância de 5%. Resultado: A prevalência de erosão dentária na população avaliada foi de 78,2%. Não foi possível associar a presença das lesões com os fatores socioeconômicos e dietéticos. Apenas a variável Aplicação Tópica de Flúor (ATF) apresentou relação estatisticamente significativa (p=0,012). Conclusão: A alta prevalência de erosão dentária na população avaliada demonstra a necessidade da implementação de medidas assistenciais e preventivas, em curto e longo prazo.Descritores: Erosão dentária; epidemiologia; crianças. AbstractIntroduction: Dental erosion is the irreversible loss of dental tissue, without bacterial involvement, whose increased prevalence in recent years has been alarming. Objective: To determine the prevalence of dental erosion, as well as associated factors, in school children from 06 to 13 years of age, in the city of Campina Grande, PB. Material and method: Selection of schools was performed by simple random sampling without replacement. After signing the Informed Consent Term and Assent Term, the examinations were performed by a previously calibrated examiner, with the child sitting in a school chair in front of the examiner in natural light. To determine the presence and degree of dental erosion, the BEWE index was used. Data were analyzed using Statistical Package for Social Sciences (SPSS for Windows, version 18.0, SPSS Inc, Chicago, IL, USA) and a significance level of 5% was used. Result: The prevalence of dental erosion in the evaluated population was 78.2%. It was not possible to associate the presence of lesions with socioeconomic and dietary factors. Only the variable Topical Application of Fluoride (TFA) presented a statistically significant relation (p = 0.012...
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