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The aim of the present research is to determine the influence of the calcification of human mitral valves on the mechanical properties of their marginal chordae tendineae. The study was performed on marginal chords obtained from thirteen human mitral valves, explanted at surgery, including six non-calcified, four moderately calcified and three strongly calcified valves. The mechanical response of the chords from the non-calcified and moderately calcified valves was determined by means of quasi-static tensile tests (the poor condition of the strongly calcified valves prevented them from being mechanically characterised). The material parameters that were obtained and analysed (the Young's modulus, the secant modulus, the proportional limit stress, the ultimate strength, the strain at fracture and the density of energy stored up to maximum load) revealed noticeable differences in mechanical behaviour between the two groups of mitral chordae tendineae. Large scatter was obtained in all cases, nevertheless, considering the mean values, it was observed that the normal chords are between three and seven times stiffer or more resistant than the moderately calcified ones. On the contrary, the results obtained for the strain at fracture showed a rather different picture as, in this case, no significant differences were observed between the two families of chords. A scanning electron microscopy study was conducted in order to find out the relevant features of the calcium deposits present in the calcified chordae tendineae. In addition, the general aspects appreciated in the stress vs. strain curves were correlated with the collagen morphological evidences determined microscopically. Finally, the calcium content present in the three groups of chords was quantitatively determined through atomic absorption spectroscopy; then, the relation between the mechanical properties of normal and moderately calcified chords as a function of its calcium content was obtained. This analysis confirmed the existence of a strong correlation between calcium content and stiffness or resistance whereas the influence on the ductility seems to be negligible.

Research and development of technology for railways has found new impetus as society continues to search for cost effective and sustainable means of transport. This tasks engineers with using the stateof-the-art science and engineering for rolling stock development and advanced technologies for building high performance, reliable and cost-effective rail infrastructures. The main goal of this work is to develop detailed and validated three-dimensional slab track models using a finite element formulation, which include all components of the infrastructure. For this purpose, the parameters of the computational models are identified by performing full-scale tests of the fastening system and of the slab track, including all its material layers. The computational model proposed here is calibrated using this approach and a good agreement is obtained between experimental and numerical results. This work opens good perspectives to use this reliable track model to study the interaction with railway vehicles in realistic operation scenarios in order to assess the dynamic behaviour of the trains and to predict the long-term performance of the infrastructure and of its components.

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