2012
DOI: 10.1016/j.jmbbm.2012.03.016
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Determination of the mechanical properties of normal and calcified human mitral chordae tendineae

Abstract: The aim of the present research is to determine the influence of the calcification of human mitral valves on the mechanical properties of their marginal chordae tendineae. The study was performed on marginal chords obtained from thirteen human mitral valves, explanted at surgery, including six non-calcified, four moderately calcified and three strongly calcified valves. The mechanical response of the chords from the non-calcified and moderately calcified valves was determined by means of quasi-static tensile t… Show more

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Cited by 23 publications
(28 citation statements)
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“…By comparing our histological and SEM images with those of human specimens from the literature we were able to confirm the similarities in structure between the two tissue types [4,6,8]. Our results for the UTS of porcine CT also closely matched the human data from the literature (average UTS of 63 ± 36.5 MPa, compared to the human results of 46 ± 28 MPa), showing that the porcine heart is a good model for approximating the mechanical properties of the human heart [13]. The tissue used was frozen for preservation prior to testing.…”
Section: Discussionsupporting
confidence: 82%
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“…By comparing our histological and SEM images with those of human specimens from the literature we were able to confirm the similarities in structure between the two tissue types [4,6,8]. Our results for the UTS of porcine CT also closely matched the human data from the literature (average UTS of 63 ± 36.5 MPa, compared to the human results of 46 ± 28 MPa), showing that the porcine heart is a good model for approximating the mechanical properties of the human heart [13]. The tissue used was frozen for preservation prior to testing.…”
Section: Discussionsupporting
confidence: 82%
“…In the toe region of the stress-strain curve, the crimp elongates and straightens to align with the direction of loading. Once the crimp is straightened, the network of fibrils covering the crimped fibres straightens and collapses, and finally the inter-fibrillar bonds are strained [9,10,13,14]. In older patients, there is a slackened and elongated crimp pattern to begin with, which may decrease the recovery power of the CT [8,9,12].…”
Section: Discussionmentioning
confidence: 99%
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“…Como diferentes cordas se inserem em diferentes locais das cúspides, elas estão expostas a diferentes condições mecânicas, sendo assim, não é surpreendente que elas tenham estruturas internas diferentes 27,28,29 . Cordas mais espessas são mais extensíveis que cordas finas.…”
Section: Resistência Mecânicaunclassified