Introduction: Perinatal asphyxia is one of the main causes of perinatal mortality and morbidity worldwide and it generates high costs for health systems; however, it has modifiable risk factors. Objective: To identify the risk factors associated with the development of perinatal asphyxia in newborns at Hospital Universitario del Valle, Cali, Colombia. Materials and methods: Incident cases and concurrent controls were examined. Cases were defined as newborns with moderate to severe perinatal asphyxia who were older than or equal to 36 weeks of gestational age, needed advanced resuscitation and presented one of the following: early neurological disorders, multi-organ commitment or a sentinel event. The controls were newborns without asphyxia who were born one week apart from the case at the most and had a comparable gestational age. Patients with major congenital malformations and syndromes were excluded. Results: Fifty-six cases and 168 controls were examined. Premature placental abruption (OR=41.09; 95%CI: 4.61-366.56), labor with a prolonged expulsive phase (OR=31.76; 95%CI: 8.33-121.19), lack of oxytocin use (OR=2.57; 95% CI: 1.08 -6.13) and mothers without a partner (OR=2.56; 95% CI: 1.21-5.41) were risk factors for the development of perinatal asphyxia in the study population. Social difficulties were found in a greater proportion among the mothers of cases. Conclusions: Proper control and monitoring of labor, development of a thorough partograph, and active searches are recommended to ensure that all pregnant women have adequate prenatal care with the provision of social support to reduce the frequency and negative impact of perinatal asphyxia.

Coffee is the second most popular drink worldwide, and it has various components with antioxidant and antitumor properties. Due to its chemical composition, it could act as an antitumor substance in the gastrointestinal tract. The objective of this study was to explore the relationship between coffee consumption and the incidence/mortality of stomach cancer in the highest-consuming countries. An ecological study using Spearman's correlation coefficient was performed. The WorldAtlas's dataset of coffee consumption and the incidence/mortality rates database of the International Agency for Research were used as sources of information. A total of 25 countries were entered to the study. There was an inverse linear correlation between coffee consumption in kg per person per year and estimated age-adjusted incidence (r = 0.5984, p = 0.0016) and mortality (r = 0.5877, p = 0.0020) of stomach cancer. Coffee may potentially have beneficial effects on the incidence and mortality of stomach cancer, as supported by the data from each country analyzed.

To describe our experience upon developing and implementing a hospital-based cancer registry (HBCR) in a quaternary-level of care private non-pro t academic medical center in Cali, Colombia. MethodsHBCRs capture, in a given institution, every single patient with a con rmed malignancy. In this study, all cases evaluated between 2014 and 2018 were included in the HBCR. In compliance with the International Agency for Research on Cancer (IARC) recommendations, cases were classi ed as analytic or nonanalytic. Data derived from an exhaustive selection of patients was stored in a computing platform owned by the institution, meeting the 2016 Facility Oncology Registry Data Standards (FORDS) recommendations. Quality control was performed by evaluating comparability, timeliness, validity, and completeness. ResultsA total of 24,405 new cases were registered between 2014 and 2018, from which 4,253 (17.4%) died. Among all cases, based on the anatomic location, most common malignancies were breast (n = 1,554), thyroid (n = 1,346), hematolymphoid (n = 1,251), prostatic (n = 805), and colorectal (n = 624). The behavior of the incidence was consistent with an incremental trend. ConclusionUpon implementing the HBCR, major challenges were identi ed (i.e. a precise de nition of cases, the development of processes for capturing new cases, a standardized data collection strategy, and carryingout an appropriate patient follow-up). Based on our experience, the success of an HBCR largely relies on the interest from the institution, the engagement of stakeholders and nancial support, that is, it depends on the adequate access over time to funding, technological, and sta ng resources.There are mainly two types of cancer registries. One that measures the impact of the disease in speci c demographics, known as Population-Based Cancer Registry (PBCR) [3]. On the other hand, Hospital-Based Cancer Registries (HBCRs), mainly evaluate the burden of the disease and the quality of healthcare services, as well as the organizational and administrative support from the institution [4,5]. Although PBCRs are a valuable source of information, in Colombia, these do not often include clinical data, thus limiting the assessment of important variables, such as accuracy of diagnosis, quality of treatment, demand for health services, among others [6].Although the bene ts of implementing an HBCR have been evidenced [7, 8], its success over time requires the interest from the institution, the engagement of stakeholders and nancial support. For instance, in Colombia, the National Cancer Institute (INC by its Spanish acronym: Instituto Nacional de Cancerología) is the only institution with an HBCR that has published data [9,10]. The purpose of this study is to describe our experience upon developing and implementing the Institutional Cancer Registry (RIC by its Spanish acronym: Registro Institucional de Cáncer) in Fundación Valle del Lili (FVL). Our methodology may serve as a role model for other health centers in the country, Latin America and the Caribbean. The ...

Cancer is one of the most burdening global health challenges. Indigenous communities are at high risk for worse healthcare outcomes because of inequalities in the incidence, prevalence, and mortality of oncological diseases, that arise from socioeconomic, racial, cultural, religious beliefs, and ethnic factors. Their perception about themselves is closely related to what affects their territory, making them possess a profound rooted feeling with their surroundings, and intense spiritual believes. Consequently, the disease process is linked to physical and emotional imbalances and alterations in their territory. Researchers from the United States, Canada, New Zealand, and Australia have worked diligently to learn about barriers to cancer management among these populations. Unfortunately, robust cancer data is lacking for most of the world's Indigenous, leading to obstacles in information systems and consequently, inequities in healthcare with the perpetuation of the problem. Therefore, a better understanding of cancer as a global health problem is required. Our study aims to propose a holistic and culturally adapted framework to improve cancer health services and outcomes among Indigenous peoples in Colombia.

Background: Coffee is the second most popular drink in the worldwide, and it has different components with antioxidant and antitumor properties. The objective of this study was to explore the relationship between coffee consumption and the incidence and mortality of stomach cancer in the main consuming countries. Methods: An observational study was performed. Dataset of coffee consumption was obtained from WorldAtlas, and incidence and mortality rates from GLOBOCAN database. Spearman's rank correlation coefficient was calculated. All statistical analysis were performed using STATA software. Results: A total of 25 countries were included in the study. There was a significant linear correlation between coffee consumption kg per person per year and an estimated age-adjusted incidence (r=0.5984, p=0.0016) and mortality (r=0.5877, p=0.0020). Conclusion: Coffee consumption could potentially have beneficial effects on incidence and mortality by stomach cancer.

BackgroundGastric adenocarcinoma (GA) has changed in recent decades. Cancer estimates are often calculated from population-based cancer registries, which lack valuable information to guide decision-making (clinical outcomes). We describe the trends in clinical practice for GA using a hospital-based cancer registry over a timespan of 15 years.MethodsA retrospective cohort study was conducted. Data were gathered from adults diagnosed and treated for GA at Fundación Valle del Lili (FVL), between 2000 and 2014, from the hospital’s own cancer registry and crossed with Cali’s Cancer Registry. Additional data were obtained directly from clinical records, pathology reports and the clinical laboratory. Patients younger than 18 years and those for whom limited information was available in the medical history were excluded. A survival analysis was conducted using Kaplan-Meier method.ResultsA total of 500 patients met eligibility criteria. Median age was 64 years (IQR: 54-74 years), 39.8% were female, 22.2% were at an early stage, 32.2% had a locally advanced disease, and 29% a metastatic disease, 69% had intestinal subtype, 48.6% had a positive H. pylori test, 85.2% had a distal lesion, 62% underwent gastrectomy, 60.6% lymphadenectomy, and 40.6% received chemotherapy. Survival at 5 years for all cases was 39.9% (CI 95% 35.3-44.5). Survival decreased over time in all groups and was lower in age-groups <39 and 60-79 with either locally advanced or metastatic disease. Prognostic factors that were significant in the Cox proportional-hazards model were late stages of the tumor (locally advanced: HR=2.52; metastatic: HR=4.17), diffuse subtype (HR=1.40), gastrectomy (subtotal: HR=0.42; total: 0.44) and palliative chemotherapy (HR=0.61).ConclusionsThe treatment of GA has changed in recent decades. GA survival was associated with clinical staging, diffuse subtype, gastrectomy and palliative chemotherapy. These findings must be interpreted in the context of a hospital-based study.

Purpose To describe our experience upon developing and implementing a hospital-based cancer registry (HBCR) in a quaternary-level of care private non-profit academic medical center in Cali, Colombia. Methods HBCRs capture, in a given institution, every single patient with a confirmed malignancy. In this study, all cases evaluated between 2014 and 2018 were included in the HBCR. In compliance with the International Agency for Research on Cancer (IARC) recommendations, cases were classified as analytic or non-analytic. Data derived from an exhaustive selection of patients was stored in a computing platform owned by the institution, meeting the 2016 Facility Oncology Registry Data Standards (FORDS) recommendations. Quality control was performed by evaluating comparability, timeliness, validity, and completeness. Results A total of 24,405 new cases were registered between 2014 and 2018, from which 4,253 (17.4%) died. Among all cases, based on the anatomic location, most common malignancies were breast (n = 1,554), thyroid (n = 1,346), hematolymphoid (n = 1,251), prostatic (n = 805), and colorectal (n = 624). The behavior of the incidence was consistent with an incremental trend. Conclusion Upon implementing the HBCR, major challenges were identified (i.e. a precise definition of cases, the development of processes for capturing new cases, a standardized data collection strategy, and carrying-out an appropriate patient follow-up). Based on our experience, the success of an HBCR largely relies on the interest from the institution, the engagement of stakeholders and financial support, that is, it depends on the adequate access over time to funding, technological, and staffing resources.

El piebaldismo es una enfermedad congénita rara de curso estático, con prevalencia de 1/100.000; se caracteriza por despigmentación en parches de la piel y presencia de un mechón blanco frontal. Por lo demás los pacientes son sanos. Se hereda con un patrón autosómico dominante. Es causado por mutaciones en el gen c-kit, un protoncogén que participa en la migración, proliferación, diferenciación y supervivencia de los melanoblastos. Por otro lado, el síndrome de Moebius es una parálisis congénita del VII par craneal, que puede estar asociada a compromiso de otros pares craneales, o incluso de otros sistemas. En Estados Unidos se ha calculado su frecuencia en 0,002 % -0,0002 % del total de nacimientos. Presentamos el caso de una recién nacida con piebaldismo y síndrome de Moebius asociado a exposición prenatal a misoprostol. Se hace una búsqueda bibliográfica sobre las anomalías de la paciente y la asociación entre la exposición prenatal a misoprostol y anomalías congénitas. El piebaldismo es un trastorno raro de etiología genética. El síndrome de Moebius, en cambio, es de causa heterogénea y no bien definida, y se ha asociado a exposición prenatal a misoprostol. La paciente reportada presenta simultáneamente ambas entidades, una netamente genética y la otra posiblemente teratogénica. PALABRAS CLAVEDefectos Congénitos; Embarazo; Hipopigmentación; Misoprostol; Piebaldismo; Síndrome de Mobius SUMMARY Piebaldism-Moebius and prenatal exposure to misoprostol: a case report Piebaldism is a rare congenital disease with prevalence of 1/100.000, characterized by patchy depigmentation of the skin and the presence of a white forelock. Its course is static and otherwise patients are healthy. It is inherited in an autosomal dominant pattern and is caused