Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

Parra-Lara, Luis Gabriel; Mendoza-Urbano, Diana Marcela; Bravo, Juan Carlos; Salamanca, Constaín H.; Zambrano, Ángela R.

doi:10.3390/nu12103028

Cited by 5 publications

(7 citation statements)

References 30 publications

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“…Second, soybean and soy products also included saponins, which were reported as an antitumor ingredient ( 27 ). Similar to other studies, our research has shown that a higher consumption of coffee and dairy products could decrease the risk of gastric cancer ( 28 , 29 ). There were several mechanisms to explain this association: (1) coffee was a mix of bioactive compounds.…”

Section: Discussionsupporting

confidence: 91%

Dietary patterns and risk for gastric cancer: A case-control study in residents of the Huaihe River Basin, China

Zhang²,

Guo³

et al. 2023

Front. Nutr.

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AimEvidence linking dietary patterns and the risk of gastric cancer was limited, especially in Chinese populations. This study aimed to explore the association between dietary patterns and the risk of gastric cancer in residents of the Huaihe River Basin, China.MethodsThe association between dietary patterns and the risk of gastric cancer was investigated through a case-control study. Dietary patterns were identified with factor analysis based on responses to a food frequency questionnaire (FFQ). Gastric cancer was diagnosed according to the International Classification of Diseases, 10th Revision (ICD 10). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated across the tertiles of dietary pattern scores using unconditional logistic regression models.ResultsA total of 2,468 participants were included in this study. Six main dietary patterns were extracted, and those patterns explained 57.09% of the total variation in food intake. After adjusting for demographic characteristics, lifestyle factors, individual disease history, family history of cancer and Helicobacter. Pylori (H. pylori) infection, comparing the highest with the lowest tertiles of dietary pattern scores, the multivariable ORs (95% CIs) were 0.786 (0.488, 1.265; Ptrend < 0.001) for the flavors, garlic and protein pattern, 2.133 (1.299, 3.502; Ptrend < 0.001) for the fast food pattern, 1.050 (0.682, 1.617; Ptrend < 0.001) for the vegetable and fruit pattern, 0.919 (0.659, 1.282; Ptrend < 0.001) for the pickled food, processed meat products and soy products pattern, 1.149 (0.804, 1.642; Ptrend < 0.001) for the non-staple food pattern and 0.690 (0.481, 0.989; Ptrend < 0.001) for the coffee and dairy pattern.ConclusionsThe specific dietary patterns were associated with the risk of gastric cancer. This study has implications for the prevention of gastric cancer.

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Section: Discussionsupporting

confidence: 91%

Dietary patterns and risk for gastric cancer: A case-control study in residents of the Huaihe River Basin, China

Zhang²,

Guo³

et al. 2023

Front. Nutr.

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“…Several prior clinical studies suggested the cancer protective effects of coffee consumption [10,18,19]. The concordant association of coffee consumption with protection from gastric cancer, hepatic cancer, breast cancer, and thyroid cancer has been reported in both Western and Asian studies [10,[18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 89%

“…The risk of gastric cancer was found to be lower among coffee consumers in a meta-analysis of case-control studies (RR = 0.85, 95% CI = 0.77-0.95) [18]. In an ecological study, countries with high coffee consumption showed a decreased incidence and mortality of gastric cancer compared to countries with lower coffee consumption (Spearman's correlation r = −0.5984, p = 0.0016) [19]. The incidence of hepatic cancer also showed an inverse association with coffee consumption in a meta-analysis study in Japan (RR = 0.50, 95% CI = 0.38-0.66, p < 0.001) [20].…”

Section: Discussionmentioning

confidence: 98%

Association between Coffee Consumption/Physical Exercise and Gastric, Hepatic, Colon, Breast, Uterine Cervix, Lung, Thyroid, Prostate, and Bladder Cancer

et al. 2021

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Although the effects of coffee consumption and physical exercise on the risk of cancer have been suggested, their interactions have not been investigated. The present cross-sectional study aimed to investigate the correlation of coffee consumption and physical exercise with cancer. Participants ≥40 years old in the Korean Genome and Epidemiology Study 2004–2016 were included (n = 162,220). Histories of gastric cancer, hepatic cancer, colon cancer, breast cancer, uterine cervix cancer, lung cancer, thyroid cancer, prostate cancer, and bladder cancer were analyzed according to the coffee consumption groups using logistic regression models. The odds among individuals in the >60 cups/month coffee group were lower for gastric cancer (adjusted odds ratio (aOR) = 0.80 (95% confidence intervals = 0.65–0.98)), hepatic cancer (0.32 (0.18–0.58)), colon cancer (0.53 (0.39–0.72)), breast cancer (0.56 (0.45–0.70)), and thyroid cancer (0.71 (0.59–0.85)) than for individuals in the no coffee group. Physical exercise of ≥150 min/week was correlated with higher odds for gastric cancer (1.18 (1.03–1.36)), colon cancer (1.52 (1.26–1.83)), breast cancer (1.53 (1.35–1.74)), thyroid cancer (1.42 (1.27–1.59)), and prostate cancer (1.61 (1.13–2.28)) compared to no exercise. Coffee consumption and physical exercise showed an interaction in thyroid cancer (p = 0.002). Coffee consumption was related to a decreased risk of gastric cancer, hepatic cancer, colon cancer, breast cancer, and thyroid cancer in the adult population. Physical exercise was positively correlated with gastric cancer, colon cancer, breast cancer, thyroid cancer, and prostate cancer.

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“…Moreover, our ndings are also related to Alzheimer's disease, colorectal cancer, intellectual disability, melanoma, lung cancer, cardiovascular disease. Interestingly, there is evidence that these diseases are related to coffee consumption (5,55).…”

Section: Discussionmentioning

confidence: 99%

“…ALDH2 polymorphism changes the risk of gastric cancer (53), and ARPC2 plays an analgesic effect in gastric cancer, providing a new target for gastric cancer treatment (54). It is worth noting that the relationship between gastric cancer and coffee consumption has also been con rmed, and coffee may have a potentially bene cial effect on the incidence and mortality of gastric cancer (55). Moreover, our ndings are also related to Alzheimer's disease, colorectal cancer, intellectual disability, melanoma, lung cancer, cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

Li¹,

Liang²,

Jia³

et al. 2021

Preprint

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Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee consumption subtypes was performed by integrating two independent genome-wide association study (GWAS) datasets (91,462–502,650 subjects) with two reference human brain proteomes (ROS/MAP and Banner), by using the FUSION pipeline. Second, transcriptome-wide association study (TWAS) analysis of coffee consumption subtypes was conducted by integrating the two gene expression weight references (RNAseq and splicing) of brain RNA-seq and the two GWAS datasets (91,462–502,650 subjects) of coffee consumption subtypes. Finally, we used the LD Score Regression (LDSC) analysis to evaluate the genetic correlations of coffee consumption subtypes with plasma proteomes and peripheral metabolites. Results For the traits related to coffee consumption, we identified 3 common PWAS proteins, such as MADD (P PWAS−Banner−dis=0.0114, P PWAS−ROS/MAP−rep =0.0489). In addition, 11 common TWAS genes were found in two cohorts, such as ARPC2 (P TWAS−splicing−dis =2063×10− 12, P TWAS−splicing−dis =1.25×10− 10, P TWAS−splicing−dis =1.24e-08, P TWAS−splicing−rep =3.25×10− 9 and P TWAS−splicing−rep =3.42×10− 13). Importantly, we have identified 8 common genes between PWAS and TWAS, such as ALDH2 (P PWAS−banner−rep =1.22×10− 22, PTWAS− splicing−dis = 4.54×10− 92). For the LDSC analysis of human plasma proteome, we identified 11 plasma proteins, such as CHL1 (P dis = 0.0151, P rep =0.0438). For the LDSC analysis of blood metabolites, 5 metabolites have been found, such as myo-inositol (P dis = 0.0073, P dis = 0.0152, P dis =0.0414, P rep =0.0216). Conclusions We identified several brain proteins and genes associated with coffee consumption subtypes. In addition, we also detected several candidate plasma proteins and metabolites related to these subtypes.

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Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

Cited by 5 publications

References 30 publications

Dietary patterns and risk for gastric cancer: A case-control study in residents of the Huaihe River Basin, China

Dietary patterns and risk for gastric cancer: A case-control study in residents of the Huaihe River Basin, China

Association between Coffee Consumption/Physical Exercise and Gastric, Hepatic, Colon, Breast, Uterine Cervix, Lung, Thyroid, Prostate, and Bladder Cancer

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

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